Abstract
The wheal and flare response to intradermal bradykinin was studied in man. The possibility that histamine and cyclooxygenase products are involved in the response to bradykinin was examined. Terfenadine given by mouth significantly inhibited the cutaneous response to histamine but the effect of bradykinin was unaltered. Similarly the cutaneous response to bradykinin was unchanged by aspirin.
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Selected References
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- Barnes P. J., Brown M. J., Dollery C. T., Fuller R. W., Heavey D. J., Ind P. W. Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Br J Pharmacol. 1986 Aug;88(4):741–745. doi: 10.1111/j.1476-5381.1986.tb16246.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuller R. W., Conradson T. B., Dixon C. M., Crossman D. C., Barnes P. J. Sensory neuropeptide effects in human skin. Br J Pharmacol. 1987 Dec;92(4):781–788. doi: 10.1111/j.1476-5381.1987.tb11381.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuller R. W., Dixon C. M., Cuss F. M., Barnes P. J. Bradykinin-induced bronchoconstriction in humans. Mode of action. Am Rev Respir Dis. 1987 Jan;135(1):176–180. doi: 10.1164/arrd.1987.135.1.176. [DOI] [PubMed] [Google Scholar]
- Fuller R. W., Warren J. B., McCusker M., Dollery C. T. Effect of enalapril on the skin response to bradykinin in man. Br J Clin Pharmacol. 1987 Jan;23(1):88–90. doi: 10.1111/j.1365-2125.1987.tb03014.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heavey D. J., Barrow S. E., Hickling N. E., Ritter J. M. Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man. Nature. 1985 Nov 14;318(6042):186–188. doi: 10.1038/318186a0. [DOI] [PubMed] [Google Scholar]
- Williams T. J., Peck M. J. Role of prostaglandin-mediated vasodilatation in inflammation. Nature. 1977 Dec 8;270(5637):530–532. doi: 10.1038/270530a0. [DOI] [PubMed] [Google Scholar]
- Williams T. J. Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation. Br J Pharmacol. 1979 Mar;65(3):517–524. doi: 10.1111/j.1476-5381.1979.tb07860.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
