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. 1988 Sep;26(3):279–284. doi: 10.1111/j.1365-2125.1988.tb05278.x

Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction.

I Macquin-Mavier 1, F Roudot-Thoraval 1, C Clerici 1, C George 1, A Harf 1
PMCID: PMC1386540  PMID: 2902873

Abstract

1. The effects of single oral doses of 10 mg bisoprolol and 400 mg acebutolol on respiratory function were studied in nine smokers with airway obstruction in a double-blind, placebo-controlled experiment. 2. The effects of the drugs were assessed by measuring specific airway conductance (sGaw) for 3 h after their administration and by studying their interaction with the bronchodilator response to inhaled salbutamol. 3. sGaw did not change for 3 h after bisoprolol or acebutolol administration. The bronchodilator response to inhaled salbutamol was not affected by bisoprolol but significantly reduced by acebutolol (P less than 0.05 vs placebo). 4. Under these conditions, bisoprolol behaves like a selective beta 1-adrenoceptor antagonist but acebutolol exhibits less beta 1-adrenoceptor selectivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dorow P., Bethge H., Tönnesmann U. Effects of single oral doses of bisoprolol and atenolol on airway function in nonasthmatic chronic obstructive lung disease and angina pectoris. Eur J Clin Pharmacol. 1986;31(2):143–147. doi: 10.1007/BF00606650. [DOI] [PubMed] [Google Scholar]
  3. Dorow P., Tönnesmann U. Dose-response relationship of the beta-adrenoceptor antagonist bisoprolol in patients with coronary heart disease and chronic obstructive bronchitis. Eur J Clin Pharmacol. 1984;27(2):135–139. doi: 10.1007/BF00544035. [DOI] [PubMed] [Google Scholar]
  4. Gribbin H. R., Mackay A. D., Baldwin C. J., Tattersfield A. E. Bronchial and cardiac beta-adrenoceptor blockade--a comparison of atenolol, acebutolol and labetalol. Br J Clin Pharmacol. 1981 Jul;12(1):61–65. doi: 10.1111/j.1365-2125.1981.tb01855.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lammers J. W., Folgering H. T., van Herwaarden C. L. Ventilatory effects of beta 1-receptor-selective blockade with bisoprolol and metoprolol in asthmatic patients. Eur J Clin Pharmacol. 1984;27(2):141–145. doi: 10.1007/BF00544036. [DOI] [PubMed] [Google Scholar]
  6. Leopold G., Ungethüm W., Pabst J., Simane Z., Bühring K. U., Wiemann H. Pharmacodynamic profile of bisoprolol, a new beta 1-selective adrenoceptor antagonist. Br J Clin Pharmacol. 1986 Sep;22(3):293–300. doi: 10.1111/j.1365-2125.1986.tb02890.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lorino A. M., Lorino H., Mariette C., Pelle G., Harf A., Atlan G. On line determination of airway resistance by plethysmography and microcomputer. Comput Biol Med. 1985;15(4):197–203. doi: 10.1016/0010-4825(85)90061-7. [DOI] [PubMed] [Google Scholar]
  8. Perks W. H., Chatterjee S. S., Croxson R. S., Cruickshank J. M. Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction. Br J Clin Pharmacol. 1978 Feb;5(2):101–106. doi: 10.1111/j.1365-2125.1978.tb01608.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Schliep H. J., Harting J. Beta 1-selectivity of bisoprolol, a new beta-adrenoceptor antagonist, in anesthetized dogs and guinea pigs. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1156–1160. [PubMed] [Google Scholar]
  10. Sinclair D. J. Comparison of effects of propranolol and metoprolol on airways obstruction in chronic bronchitis. Br Med J. 1979 Jan 20;1(6157):168–168. doi: 10.1136/bmj.1.6157.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Skinner C., Palmer K. N. Comparison of the effects of acebutolol (Sectral) and practolol (Eraldin) on airways obstruction in asthmatics. Br J Clin Pharmacol. 1975 Oct;2(5):417–422. doi: 10.1111/j.1365-2125.1975.tb00550.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tattersfield A. E. Beta adrenoceptor antagonists and respiratory disease. J Cardiovasc Pharmacol. 1986;8 (Suppl 4):S35–S39. doi: 10.1097/00005344-198608004-00007. [DOI] [PubMed] [Google Scholar]
  13. Tattersfield A. E., Cragg D. J., Bacon R. J. Assessment of beta-adrenoceptor selectivity of a new beta-adrenoceptor antagonist, bisoprolol, in man. Br J Clin Pharmacol. 1984 Sep;18(3):343–347. doi: 10.1111/j.1365-2125.1984.tb02474.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Whitsett T. L., Levin D. C., Manion C. V. Comparison of the beta 1 and beta 2 adrenoceptor blocking properties of acebutolol and propranolol. Chest. 1982 Dec;82(6):668–673. doi: 10.1378/chest.82.6.668. [DOI] [PubMed] [Google Scholar]
  15. van Herwaarden C. L. beta-Adrenoceptor blockade and pulmonary function in patients suffering from chronic obstructive lung disease. J Cardiovasc Pharmacol. 1983;5 (Suppl 1):S46–S50. doi: 10.1097/00005344-198300051-00007. [DOI] [PubMed] [Google Scholar]

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