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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1988 Sep;26(3):323–326. doi: 10.1111/j.1365-2125.1988.tb05283.x

Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.

P Crome 1, A Baksi 1, D MacMahon 1, N D Pandita-Gunawardena 1, J Edwards 1, J Marley 1
PMCID: PMC1386545  PMID: 3179170

Abstract

Twenty-three elderly hypertensive subjects received nitrendipine 10mg daily by mouth for 8 days. Plasma nitrendipine concentrations were measured after the first and last dose. There was no significant difference in plasma concentrations at any time point between the two days nor in derived pharmacokinetic measurements. Drug accumulation was not observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Kann J., Krol G. J., Raemsch K. D., Burkholder D. E., Levitt M. J. Bioequivalence and metabolism of nitrendipine administered orally to healthy volunteers. J Cardiovasc Pharmacol. 1984;6 (Suppl 7):S968–S973. [PubMed] [Google Scholar]
  2. Lasseter K. C., Shamblen E. C., Murdoch A. A., Burkholder D. E., Krol G. J., Taylor R. J., Jr, Vanov S. K. Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency. J Cardiovasc Pharmacol. 1984;6 (Suppl 7):S977–S981. [PubMed] [Google Scholar]
  3. Rawlins M. D., James O. F., Williams F. M., Wynne H., Woodhouse K. W. Age and the metabolism of drugs. Q J Med. 1987 Jul;64(243):545–547. [PubMed] [Google Scholar]
  4. Tourkantonis A., Lasaridis A., Settas L. Clinical experience with long-term nitrendipine treatment in essential hypertension. J Cardiovasc Pharmacol. 1984;6 (Suppl 7):S1090–S1095. [PubMed] [Google Scholar]

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