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. 1988 Oct;26(4):463–468. doi: 10.1111/j.1365-2125.1988.tb03406.x

An evaluation of different doses of soluble aspirin and aspirin tablets in postoperative dental pain.

I S Holland 1, R A Seymour 1, R P Ward-Booth 1, R A Ord 1, K L Lim 1, R C Hoare 1
PMCID: PMC1386569  PMID: 3190996

Abstract

1. The efficacy of three different single doses (600, 900 and 1200 mg of soluble aspirin and aspirin tablets) was determined in a randomized placebo-controlled parallel study in 140 patients (70 females) with postoperative pain after removal of impacted third molars. 2. Patients treated with soluble aspirin 600 mg, 900 mg, 1200 mg and aspirin tablet 1200 mg reported significantly less pain (P less than 0.01) throughout the investigation period than those treated with placebo. 3. Overall pain scores after treatment with aspirin tablets 600 and 900 mg did not differ significantly from those after treatment with placebo (P greater than 0.05). 4. On a comparative dose basis, soluble aspirin was significantly more potent (P less than 0.05) than aspirin tablets.

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Selected References

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  1. Beatson N. Atropine and paralytic ileus. Postgrad Med J. 1982 Jul;58(681):451–453. doi: 10.1136/pgmj.58.681.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cooper S. A., Beaver W. T. A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther. 1976 Aug;20(2):241–250. doi: 10.1002/cpt1976202241. [DOI] [PubMed] [Google Scholar]
  3. Henrikson P. A., Tjernberg A., Ahlström U., Peterson L. E. Analgesic efficacy and safety of Fenbufen following surgical removal of a lower wisdom tooth: a comparison with acetylsalicylic acid and placebo. J Int Med Res. 1979;7(2):107–116. doi: 10.1177/030006057900700201. [DOI] [PubMed] [Google Scholar]
  4. Levy G. Aspirin, absorption rate and analgesic effect. Anesth Analg. 1965 Nov-Dec;44(6):837–841. [PubMed] [Google Scholar]
  5. Proost J. H., Van Imhoff G. W., Wesseling H. Plasma levels of acetylsalicylic acid and salicylic acid after oral ingestion of plain and buffered acetylsalicylic acid in relation to bleeding time and thrombocyte function. Pharm Weekbl Sci. 1983 Feb 25;5(1):22–27. doi: 10.1007/BF01959647. [DOI] [PubMed] [Google Scholar]
  6. Rance M. J., Jordan B. J., Nichols J. D. A simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in plasma by gas liquid chromatography. J Pharm Pharmacol. 1975 Jun;27(6):425–429. doi: 10.1111/j.2042-7158.1975.tb09472.x. [DOI] [PubMed] [Google Scholar]
  7. Ross-Lee L. M., Elms M. J., Cham B. E., Bochner F., Bunce I. H., Eadie M. J. Plasma levels of aspirin following effervescent and enteric coated tablets, and their effect on platelet function. Eur J Clin Pharmacol. 1982;23(6):545–551. doi: 10.1007/BF00637504. [DOI] [PubMed] [Google Scholar]
  8. Seymour R. A., Meechan J. G., Blair G. S. An investigation into post-operative pain after third molar surgery under local analgesia. Br J Oral Maxillofac Surg. 1985 Dec;23(6):410–418. doi: 10.1016/0266-4356(85)90025-7. [DOI] [PubMed] [Google Scholar]
  9. Seymour R. A., Rawlins M. D. Efficacy and pharmacokinetics of aspirin in post-operative dental pain. Br J Clin Pharmacol. 1982 Jun;13(6):807–810. doi: 10.1111/j.1365-2125.1982.tb01870.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Seymour R. A., Walton J. G. Pain control after third molar surgery. Int J Oral Surg. 1984 Dec;13(6):457–485. doi: 10.1016/s0300-9785(84)80017-4. [DOI] [PubMed] [Google Scholar]
  11. Seymour R. A., Williams F. M., Luyk N. M., Boyle M. A., Whitfield P. M., Nicholson E., Booth P. W., Rawlins M. D. Comparative efficacy of soluble aspirin and aspirin tablets in postoperative dental pain. Eur J Clin Pharmacol. 1986;30(4):495–498. doi: 10.1007/BF00607968. [DOI] [PubMed] [Google Scholar]
  12. Seymour R. A., Williams F. M., Ward A., Rawlins M. D. Aspirin metabolism and efficacy in postoperative dental pain. Br J Clin Pharmacol. 1984 Jun;17(6):697–701. doi: 10.1111/j.1365-2125.1984.tb02406.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Skjelbred P. The effects of acetylsalicylic acid on swelling, pain and other events after surgery. Br J Clin Pharmacol. 1984 Apr;17(4):379–384. doi: 10.1111/j.1365-2125.1984.tb02361.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. von Graffenried B., Nüesch E., Maeglin B., Hägler W., Kuhn M. Assessment of analgesics in dental surgery outpatients. Eur J Clin Pharmacol. 1980 Nov;18(6):479–482. doi: 10.1007/BF00874659. [DOI] [PubMed] [Google Scholar]

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