Abstract
The kinetics of metoclopramide and the effects of haemodialysis on metoclopramide kinetics were examined in eight uraemic subjects 1 h and 24 h prior to the onset of dialysis. In spite of the relatively minor contribution of renal clearance to total body clearance in normals, metoclopramide kinetics were substantially altered in uraemia. The total body clearance was decreased by 2-4 fold, terminal elimination half-life proportionately increased, while the volume of distribution appeared to be unaffected compared with that previously demonstrated in normal healthy subjects. Haemodialysis does not appear to be effective in removing metoclopramide from the body and metoclopramide clearance subsequent to dialysis is unaltered. The kinetic parameters in the uraemic subjects are not significantly different between drug administrations 1 or 24 h prior to the time of onset of haemodialysis. Following kidney transplantation, in one subject, there appeared to be a rapid return to apparently normal kinetics from the uraemic state.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boardman L. J., Hume S. P., Lamb J. F., Polson J. Effect of growth in lithium on ouabain binding, Na-K-ATPase and Na and K transport in hela cells. J Physiol. 1975 Jan;244(3):677–682. doi: 10.1113/jphysiol.1975.sp010819. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boardman L. J., Lamb J. F., McCall D. Uptake of ( 3 H)ouabain and Na pump turnover rates in cells cultured in ouabain. J Physiol. 1972 Sep;225(3):619–635. doi: 10.1113/jphysiol.1972.sp009960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boardman L., Huett M., Lamb J. F., Newton J. P., Polson J. M. Evidence for the genetic control of the sodium pump density in HeLa cells. J Physiol. 1974 Sep;241(3):771–794. doi: 10.1113/jphysiol.1974.sp010684. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oh V. M., Taylor E. A., Ding J. L., Boon N. A., Aronson J. K., Grahame-Smith D. G. Enhancement of specific [3H]ouabain binding and ouabain sensitive 86rubidium influx in intact human lymphocytes by a dialysable factor in human and fetal calf serum. Clin Sci (Lond) 1987 Jan;72(1):71–79. doi: 10.1042/cs0720071. [DOI] [PubMed] [Google Scholar]
- Oh V. M., Taylor E. A. Effects of serum, lithium, ethacrynic acid, and low external concentration of potassium on specific [3H]-ouabain binding to human lymphocytes. Br J Clin Pharmacol. 1987 Nov;24(5):681–684. doi: 10.1111/j.1365-2125.1987.tb03231.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poston L., Jones R. B., Hilton P. J. Sodium transport on polymorphonuclear leucocytes: effect of isolation by the Ficoll/Triosil method. Clin Sci (Lond) 1982 May;62(5):563–564. doi: 10.1042/cs0620563. [DOI] [PubMed] [Google Scholar]
- Rapeport W. G., Aronson J. K., Grahame-Smith D. G., Harper C. The effects of serum, lithium, ethacrynic acid, and a low external concentration of potassium on specific [3H]-ouabain binding to human lymphocytes after incubation for 3 days. Br J Clin Pharmacol. 1986 Sep;22(3):275–279. doi: 10.1111/j.1365-2125.1986.tb02887.x. [DOI] [PMC free article] [PubMed] [Google Scholar]