Abstract
1. Three experiments were conducted to examine whether mydriatic or miotic drugs instilled into one eye have any effect on the diameter of the pupil of the untreated fellow eye, in healthy volunteers. 2. In Experiment 1, the effects of four subjects, using photography in an illuminated room to assess pupil diameter. The drug evoked a dose-dependent mydriasis in the index eye which was accompanied by a simultaneous dose-dependent miosis in the fellow eye. 3. In Experiment 2, the same method was used to assess pupil diameter as in Experiment 1. The effects of mydriatic (methoxamine and tyramine) and of miotic (pilocarpine) drugs instilled into the fellow eye, were studied on the sizes of pupillary responses to the same drugs instilled into the index eye. The presence of a mydriatic drug in the fellow eye resulted in a decrease in the size of the mydriatic responses in the index eye. 4. In Experiment 3, the effects of three concentrations of phenylephrine hydrochloride (0.15-0.60 M) and of three concentrations of pilocarpine hydrochloride (0.002-0.008 M), were studied in darkness using an infra-red binocular television pupillometer, in seven subjects. Phenylephrine evoked dose-dependent mydriasis and pilocarpine evoked dose-dependent miosis. The pupillary responses of the index eye were not accompanied by any changes in the diameter of the pupil of the fellow eye. 5. It is concluded that drug-induced mydriasis in the index eye is accompanied by a consensual miosis in the fellow eye.(ABSTRACT TRUNCATED AT 250 WORDS)
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bertler A., Smith S. E. Genetic influences in drug responses of the eye and the heart. Clin Sci. 1971 May;40(5):403–410. doi: 10.1042/cs0400403. [DOI] [PubMed] [Google Scholar]
- Birmingham A. T., Galloway N. R., Walker D. A. Intraocular pressure reduction in chronic simple glaucoma by continuous infusion of dilute pilocarpine solution. Br J Ophthalmol. 1979 Dec;63(12):808–812. doi: 10.1136/bjo.63.12.808. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haddad N. J., Moyer N. J., Riley F. C., Jr Mydriatic effect of phenylephrine hydrochloride. Am J Ophthalmol. 1970 Nov;70(5):729–733. doi: 10.1016/0002-9394(70)90490-3. [DOI] [PubMed] [Google Scholar]
- Innemee H. C., de Jonge A., van Meel J. C., Timmermans P. B., van Zwieten P. A. Differential effects of selective alpha 1- and alpha 2-adrenoceptor agonists on intraocular pressure in the conscious rabbit. Doc Ophthalmol. 1982 Jan 29;52(3-4):287–295. doi: 10.1007/BF01675858. [DOI] [PubMed] [Google Scholar]
- LOEWENFELD I. E. Mechanisms of reflex dilatation of the pupil; historical review and experimental analysis. Doc Ophthalmol. 1958;12:185–448. doi: 10.1007/BF00913471. [DOI] [PubMed] [Google Scholar]
- Sneddon J. M., Turner P. The interactions of local guanethidine and sympathomimetic amines in the human eye. Arch Ophthalmol. 1969 May;81(5):622–627. doi: 10.1001/archopht.1969.00990010624005. [DOI] [PubMed] [Google Scholar]
- WILKINSON G. N. Statistical estimations in enzyme kinetics. Biochem J. 1961 Aug;80:324–332. doi: 10.1042/bj0800324. [DOI] [PMC free article] [PubMed] [Google Scholar]