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. 1988 Nov;26(5):604–606. doi: 10.1111/j.1365-2125.1988.tb05302.x

Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.

V K Nayak 1, N A Kshirsagar 1, N K Desai 1, R S Satoskar 1
PMCID: PMC1386639  PMID: 3207565

Abstract

The effect of the menstrual cycle on antipyrine pharmacokinetics was studied in 11 normal, healthy Indian female volunteers. Antipyrine half-life, apparent volume of distribution, clearance and AUC were calculated by standard methods. Results indicated that in females, antipyrine half-life was significantly longer on day 5 as compared with that on days 15 and 21 of the menstrual cycle. It appears that hormonal changes during the menstrual cycle affect the pharmacokinetics of drugs in normal healthy females.

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Selected References

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