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. 1988 Apr;25(4):518–521. doi: 10.1111/j.1365-2125.1988.tb03338.x

The effect of metoclopramide on the absorption of oral controlled release morphine.

A R Manara 1, M P Shelly 1, K Quinn 1, G R Park 1
PMCID: PMC1387816  PMID: 3382595

Abstract

The pharmacokinetics of oral controlled release morphine and metoclopramide were investigated in 20 patients in a double-blind, randomly allocated study. The concurrent administration of metoclopramide and oral controlled release morphine led to a faster onset and increased level of sedation compared with the administration of oral controlled release morphine alone. Whilst the increased sedation may be advantageous in anaesthetic practice, it may be a potential problem in patients starting longer term therapy with these drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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