Abstract
1. An in vivo pH monitoring technique was used to assess changes in pH, and by inference changes in PCO2, in the carotid artery of anaesthetized cats. The changes in carotid artery pH and respiration following abrupt injections of various acids into the carotid artery or aorta were investigated.
2. Injections of saline equilibrated with 100% CO2, timed to produce changes at the carotid body chemoreceptors during early inspiration caused an increase in the tidal volume of that breath. The amplitude and rate of change of the pH changes so produced were comparable with those of the oscillations in pH produced by respiration itself.
3. The respiratory responses to injection of saline equilibrated with 100% CO2 occurred whether the animal was breathing air or 100% O2.
4. Injections of lactic or hydrochloric acid were without an effect on respiration, except when pH changes larger than 0·1 pH unit were produced. A NaHCO3 solution equilibrated with 30% CO2 stimulated respiration, even though the solution was alkaline to the cat's arterial blood and induced an alkaline change in arterial pH.
5. Infiltration of the carotid sinus nerve area with procaine temporarily abolished the respiratory response to injections of saline equilibrated with 100% CO2.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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