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. 1971 Feb;212(3):611–627. doi: 10.1113/jphysiol.1971.sp009345

The effect of light chloralose and pentobarbitone anaesthesia on the acid—base state and oxygenation of arterial blood in dogs

J R Ledsome, R J Linden, J Norman
PMCID: PMC1395721  PMID: 5557063

Abstract

1. The effects of light anaesthesia of approximately 8 hr duration using either pentobarbitone or chloralose on the acid—base balance and oxygenation of arterial blood were determined in dogs breathing spontaneously.

2. With pentobarbitone anaesthesia there was a slight initial respiratory acidaemia.

3. With chloralose there was a non-respiratory acidaemia which was probably the result of using an unbuffered solvent.

4. Changes in the acid—base balance and the oxygen concentration of the arterial blood over the course of each experiment were minimal.

5. In one animal a pH of 7·07 was recorded; in others the oxygen tension on occasion was between 50 and 60 mm Hg. The value of monitoring the acid—base state and the oxygenation of blood in experimental preparations is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN O. S. Blood acid-base alignment nomogram. Scales for pH, pCO2 base excess of whole blood of different hemoglobin concentrations, plasma bicarbonate, and plasma total-CO2. Scand J Clin Lab Invest. 1963;15:211–217. doi: 10.3109/00365516309079734. [DOI] [PubMed] [Google Scholar]
  2. BRADLEY A. F., SEVERINGHAUS J. W., STUPFEL M. Effect of temperature on PCO2 and PO2 of blood in vitro. J Appl Physiol. 1956 Sep;9(2):201–204. doi: 10.1152/jappl.1956.9.2.201. [DOI] [PubMed] [Google Scholar]
  3. BRADLEY A. F., SEVERINGHAUS J. W., STUPFEL M. Variations of serum carbonic acid pK with pH and temperature. J Appl Physiol. 1956 Sep;9(2):197–200. doi: 10.1152/jappl.1956.9.2.197. [DOI] [PubMed] [Google Scholar]
  4. BROWN R. V., HILTON J. G. The effectiveness of the baroreceptor reflexes under different anesthetics. J Pharmacol Exp Ther. 1956 Oct;118(2):198–203. [PubMed] [Google Scholar]
  5. BUNKER J. P., BEECHER H. K., BRIGGS B. D., BREWSTER W. R., BARNES B. A. Metabolic effects of anesthesia. II. A comparison of acid-base equilibrium in man and in dogs during ether and during cyclopropane anesthesia. J Pharmacol Exp Ther. 1951 May;102(1):62–70. [PubMed] [Google Scholar]
  6. Biscoe T. J., Sampson S. R. Stimulus response curves of single carotid body chemoreceptor afferent fibres. Nature. 1967 Aug 5;215(5101):654–655. doi: 10.1038/215654a0. [DOI] [PubMed] [Google Scholar]
  7. CAMPBELL G. S. Cardiac arrest: further studies on the effect of pH changes on vagal inhibition of the heart. Surgery. 1955 Sep;38(3):615–634. [PubMed] [Google Scholar]
  8. DOBKIN A. B., FEDORUK S. Comparison of the cardiovascular, respiratory and metabolic effects of methoxyflurane and halothane in dogs. Anesthesiology. 1961 May-Jun;22:355–362. doi: 10.1097/00000542-196105000-00004. [DOI] [PubMed] [Google Scholar]
  9. DOBKIN A. B., HARLAND J. H., FEDORUK S. Chloroform and halothane in a precision system. Br J Anaesth. 1961 May;33:239–257. doi: 10.1093/bja/33.5.239. [DOI] [PubMed] [Google Scholar]
  10. DOBKIN A. B., HARLAND J. H., FEDORUK S. Trichlorethylene and halothane in a precision system. Comparison of cardiorespiratory and metabolic effects in dogs. Anesthesiology. 1962 Jan-Feb;23:58–64. doi: 10.1097/00000542-196201000-00010. [DOI] [PubMed] [Google Scholar]
  11. Goldberg A. H. Cardiovascular function and halothane. Clin Anesth. 1968;1:23–60. [PubMed] [Google Scholar]
  12. LEDSOME J. R., LINDEN R. J. THE EFFECT OF BRETYLIUM TOSYLATE ON SOME CARDIOVASCULAR REFLEXES. J Physiol. 1964 Apr;170:442–455. doi: 10.1113/jphysiol.1964.sp007342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. LINDEN R. J., LEDSOME J. R., NORMAN J. SIMPLE METHODS FOR THE DETERMINATION OF THE CONCENTRATIONS OF CARBON DIOXIDE AND OXYGEN IN BLOOD. Br J Anaesth. 1965 Feb;37:77–88. doi: 10.1093/bja/37.2.77. [DOI] [PubMed] [Google Scholar]
  14. Ledsome J. R., Linden R. J., Norman J. An anaesthetic machine for dogs. J Physiol. 1967 Jul;191(2):61P–62P. [PubMed] [Google Scholar]
  15. Linden R. J., Norman J. The effect of acidaemia on the response to stimulation of the autonomic nerves to the heart. J Physiol. 1969 Jan;200(1):51–71. doi: 10.1113/jphysiol.1969.sp008681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MILLAR R. A., MORRIS M. E. Sympatho-adrenal responses during general anaesthesia in the dog and man. Can Anaesth Soc J. 1961 Jul;8:356–386. doi: 10.1007/BF03021356. [DOI] [PubMed] [Google Scholar]
  17. Norman J., Ledsome J. R., Linden R. J. A system for the measurement of respiratory and acid-base parameters in blood. Br J Anaesth. 1965 Jul;37(7):466–479. doi: 10.1093/bja/37.7.466. [DOI] [PubMed] [Google Scholar]
  18. VANCITTERS R. L., FRANKLIN D. L., RUSHMER R. F. LEFT VENTRICULAR DYNAMICS IN DOGS DURING ANESTHESIA WITH ALPHA-CHLORALOSE AND SODIUM PENTOBARBITAL. Am J Cardiol. 1964 Mar;13:349–354. doi: 10.1016/0002-9149(64)90451-5. [DOI] [PubMed] [Google Scholar]

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