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. 1971 Feb;212(3):667–683. doi: 10.1113/jphysiol.1971.sp009349

Biophysical properties of the longitudinal smooth muscle of the guinea-pig rectum

H Kuriyama, F Mekata
PMCID: PMC1395730  PMID: 5557067

Abstract

1. The membrane properties of the longitudinal muscle layer of the guinea-pig rectum were studied in hypertonic solution (twice the normal Krebs by addition of sucrose) by the micro-electrode technique. To produce the electrotonic potential and spike, stimulating partitions were used.

2. Hypertonic solution hyperpolarized the membrane and increased the membrane resistance. However, no change in the space constant was observed before and after treatment with hypertonic solution.

3. The appearance and amplitude of the spike became regular after treatment with hypertonic solution and appearance of the overshoot was consistent.

4. The characteristic constants and the conduction velocity were measured in hypertonic solution.

(i) The space constant of the membrane was 0·81 mm, the time constant of the electrotonic potential was 83·7 msec and the time constant of the foot of the propagated spike was 8·8 msec.

(ii) The conduction velocity of the excitation measured by insertions of the two micro-electrodes was 4·4 cm/sec.

(iii) The chronaxie of the membrane was 71·3 msec.

5. The results obtained from the present experiments were discussed in relation to the cable theory, and it was concluded that the passive properties of the membrane of the rectal smooth muscle could be explained by the cable equations.

6. The specificities of the electrical properties of rectal smooth muscle were compared with muscle from other regions of the alimentary canal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe Y., Tomita T. Cable properties of smooth muscle. J Physiol. 1968 May;196(1):87–100. doi: 10.1113/jphysiol.1968.sp008496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. FALK G., FATT P. LINEAR ELECTRICAL PROPERTIES OF STRIATED MUSCLE FIBRES OBSERVED WITH INTRACELLULAR ELECTRODES. Proc R Soc Lond B Biol Sci. 1964 Apr 14;160:69–123. doi: 10.1098/rspb.1964.0030. [DOI] [PubMed] [Google Scholar]
  3. Fozzard H. A. Membrane capacity of the cardiac Purkinje fibre. J Physiol. 1966 Jan;182(2):255–267. doi: 10.1113/jphysiol.1966.sp007823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Freygang W. H., Jr, Rapoport S. I., Peachey L. D. Some relations between changes in the linear electrical properties of striated muscle fibers and changes in ultrastructure. J Gen Physiol. 1967 Nov;50(10):2437–2458. doi: 10.1085/jgp.50.10.2437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HODGKIN A. L., HUXLEY A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544. doi: 10.1113/jphysiol.1952.sp004764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kuriyama H., Osa T., Tasaki H. Electrophysiological studies of the antrum muscle fibers of the guinea pig stomach. J Gen Physiol. 1970 Jan;55(1):48–62. doi: 10.1085/jgp.55.1.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kuriyama H., Osa T., Toida N. Electrophysiological study of the intestinal smooth muscle of the guinea-pig. J Physiol. 1967 Jul;191(2):239–255. doi: 10.1113/jphysiol.1967.sp008248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. NOBLE D. A modification of the Hodgkin--Huxley equations applicable to Purkinje fibre action and pace-maker potentials. J Physiol. 1962 Feb;160:317–352. doi: 10.1113/jphysiol.1962.sp006849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Noble D. Applications of Hodgkin-Huxley equations to excitable tissues. Physiol Rev. 1966 Jan;46(1):1–50. doi: 10.1152/physrev.1966.46.1.1. [DOI] [PubMed] [Google Scholar]
  10. Noble D., Stein R. B. The threshold conditions for initiation of action potentials by excitable cells. J Physiol. 1966 Nov;187(1):129–162. doi: 10.1113/jphysiol.1966.sp008079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. TASAKI I., HAGIWARA S. Capacity of muscle fiber membrane. Am J Physiol. 1957 Mar;188(3):423–429. doi: 10.1152/ajplegacy.1957.188.3.423. [DOI] [PubMed] [Google Scholar]
  12. Tomita T. Electrical responses of smooth muscle to external stimulation in hypertonic solution. J Physiol. 1966 Mar;183(2):450–468. doi: 10.1113/jphysiol.1966.sp007876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tomita T. Membrane capacity and resistance of mammalian smooth muscle. J Theor Biol. 1966 Nov;12(2):216–227. doi: 10.1016/0022-5193(66)90114-7. [DOI] [PubMed] [Google Scholar]
  14. Tomita T. Spike propagation in the smooth muscle of the guinea-pig taenia coli. J Physiol. 1967 Aug;191(3):517–527. doi: 10.1113/jphysiol.1967.sp008265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tomita T. The longitudinal tissue impedance of the smooth muscle of guinea-pig taenia coli. J Physiol. 1969 Mar;201(1):145–159. doi: 10.1113/jphysiol.1969.sp008748. [DOI] [PMC free article] [PubMed] [Google Scholar]

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