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. 1966 Sep;186(1):121–138. doi: 10.1113/jphysiol.1966.sp008024

Pharmacological studies on feline Betz cells

J M Crawford, D R Curtis
PMCID: PMC1395892  PMID: 5914248

Abstract

1. A study has been made of the sensitivity of single neurones in the pericruciate cortex of anaesthetized and unanaesthetized cats to cholinomimetics administered electrophoretically from multibarrel micropipettes.

2. A high proportion of deep pyramidal cells, including Betz cells, were excited by these substances, and the receptors involved have muscarinic characteristics.

3. Atropine specifically reduced the sensitivity of cortical neurones to acetylcholine, but no such action could be demonstrated for dihydro-β-erythroidine, gallamine or general anaesthetics.

4. The significance of these results is discussed in relation to the possible synaptic or non-synaptic action of acetylcholine upon cortical neurones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN P., CURTIS D. R. THE EXCITATION OF THALAMIC NEURONES BY ACETYLCHOLINE. Acta Physiol Scand. 1964 May-Jun;61:85–99. doi: 10.1111/j.1748-1716.1964.tb02945.x. [DOI] [PubMed] [Google Scholar]
  2. ANDERSEN P., CURTIS D. R. THE PHARMACOLOGY OF THE SYNAPTIC AND ACETYLCHOLINE-INDUCED EXCITATION OF VENTROBASAL THALAMIC NEURONES. Acta Physiol Scand. 1964 May-Jun;61:100–120. doi: 10.1111/j.1748-1716.1964.tb02946.x. [DOI] [PubMed] [Google Scholar]
  3. BISCOE T. J., STRAUGHAN D. W. THE PHARMACOLOGY OF HIPPOCAMPAL NEURONES. J Pharm Pharmacol. 1965 Jan;17:60–61. doi: 10.1111/j.2042-7158.1965.tb07571.x. [DOI] [PubMed] [Google Scholar]
  4. CRAWFORD J. M., CURTIS D. R. THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS. Br J Pharmacol Chemother. 1964 Oct;23:313–329. doi: 10.1111/j.1476-5381.1964.tb01589.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CURTIS D. R., DAVIS R. Pharmacological studies upon neurones of the lateral geniculate nucleus of the cat. Br J Pharmacol Chemother. 1962 Apr;18:217–246. doi: 10.1111/j.1476-5381.1962.tb01404.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CURTIS D. R., PHILLIS J. W. The action of procaine and atropine on spinal neurones. J Physiol. 1960 Aug;153:17–34. doi: 10.1113/jphysiol.1960.sp006516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. CURTIS D. R., WATKINS J. C. Acidic amino acids with strong excitatory actions on mammalian neurones. J Physiol. 1963 Apr;166:1–14. doi: 10.1113/jphysiol.1963.sp007087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Crawford J. M., Curtis D. R., Voorhoeve P. E., Wilson V. J. Acetylcholine sensitivity of cerebellar neurones in the cat. J Physiol. 1966 Sep;186(1):139–165. doi: 10.1113/jphysiol.1966.sp008025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Curtis D. R., Crawford J. M. Acetylcholine sensitivity of cerebellar neurones. Nature. 1965 May 1;206(983):516–517. doi: 10.1038/206516a0. [DOI] [PubMed] [Google Scholar]
  10. Curtis D. R., Ryall R. W. The acetylcholine receptors of Renshaw cells. Exp Brain Res. 1966;2(1):66–80. doi: 10.1007/BF00234361. [DOI] [PubMed] [Google Scholar]
  11. Curtis D. R., Ryall R. W. The excitation of Renshaw cells by cholinomimetics. Exp Brain Res. 1966;2(1):49–65. doi: 10.1007/BF00234360. [DOI] [PubMed] [Google Scholar]
  12. Curtis D. R., Ryall R. W. The synaptic excitation of Renshaw cells. Exp Brain Res. 1966;2(1):81–96. doi: 10.1007/BF00234362. [DOI] [PubMed] [Google Scholar]
  13. Curtis D. R., Ryall R. W., Watkins J. C. The action of cholinomimetics on spinal interneurones. Exp Brain Res. 1966;2(1):97–106. doi: 10.1007/BF00234363. [DOI] [PubMed] [Google Scholar]
  14. HEBB C. O. Biochemical evidence for the neural function of acetylcholine. Physiol Rev. 1957 Apr;37(2):196–220. doi: 10.1152/physrev.1957.37.2.196. [DOI] [PubMed] [Google Scholar]
  15. KRNJEVIC K., PHILLIS J. W. Acetylcholine-sensitive cells in the cerebral cortex. J Physiol. 1963 Apr;166:296–327. doi: 10.1113/jphysiol.1963.sp007106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. KRNJEVIC K., PHILLIS J. W. Actions of certain amines on cerebral cortical neurones. Br J Pharmacol Chemother. 1963 Jun;20:471–490. doi: 10.1111/j.1476-5381.1963.tb01484.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. KRNJEVIC K., PHILLIS J. W. Iontophoretic studies of neurones in the mammalian cerebral cortex. J Physiol. 1963 Feb;165:274–304. doi: 10.1113/jphysiol.1963.sp007057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Krnjević K., Phillis J. W. Pharmacological properties of acetylcholine-sensitive cells in the cerebral cortex. J Physiol. 1963 May;166(2):328–350. doi: 10.1113/jphysiol.1963.sp007107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Krnjević K., Silver A. A histochemical study of cholinergic fibres in the cerebral cortex. J Anat. 1965 Oct;99(Pt 4):711–759. [PMC free article] [PubMed] [Google Scholar]
  20. Mitchell J. F. The spontaneous and evoked release of acetylcholine from the cerebral cortex. J Physiol. 1963 Jan;165(1):98–116. doi: 10.1113/jphysiol.1963.sp007045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. PHILLIPS C. G. Actions of antidromic pyramidal volleys on single Betz cells in the cat. Q J Exp Physiol Cogn Med Sci. 1959 Jan;44(1):1–25. doi: 10.1113/expphysiol.1959.sp001364. [DOI] [PubMed] [Google Scholar]
  22. PHILLIPS C. G. Intracellular records from Betz cells in the cat. Q J Exp Physiol Cogn Med Sci. 1956 Jan;41(1):58–69. doi: 10.1113/expphysiol.1956.sp001163. [DOI] [PubMed] [Google Scholar]
  23. RANDIC M., SIMINOFF R., STRAUGHAN D. W. ACETYLCHOLINE DEPRESSION OF CORTICAL NEURONS. Exp Neurol. 1964 Mar;9:236–242. doi: 10.1016/0014-4886(64)90020-2. [DOI] [PubMed] [Google Scholar]
  24. SALMOIRAGHI G. C., STEINER F. A. Acetylcholine sensitivity of cat's medullary neurons. J Neurophysiol. 1963 Jul;26:581–597. doi: 10.1152/jn.1963.26.4.581. [DOI] [PubMed] [Google Scholar]
  25. SPEHLMANN R. Acetylcholine and prostigmine electrophoresis at visual cortex neurons. J Neurophysiol. 1963 Jan;26:127–139. doi: 10.1152/jn.1963.26.1.127. [DOI] [PubMed] [Google Scholar]
  26. VERZEANO M., CALMA I. Unit activity in spindle bursts. J Neurophysiol. 1954 Sep;17(5):417–428. doi: 10.1152/jn.1954.17.5.417. [DOI] [PubMed] [Google Scholar]
  27. Watkins J. C. Pharmacological receptors and general permeability phenomena of cell membranes. J Theor Biol. 1965 Jul;9(1):37–50. doi: 10.1016/0022-5193(65)90055-x. [DOI] [PubMed] [Google Scholar]

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