Abstract
1. A direct method for measuring venous outflow from brown adipose tissue in anaesthetized new-born rabbits is described.
2. During noradrenaline infusion the mean blood flow through brown adipose tissue increased from 87 to 360 ml./100 g tissue (wet wt.).min, and the mean rate of oxygen consumption of brown adipose tissue rose from 9·3 to 60 ml. O2/100 g tissue.min.
3. During cold exposure the mean blood flow through brown adipose tissue increased from 90 to 304 ml./100 g tissue.min.
4. The mean cardiac output was 266 ml./kg body weight.min; during noradrenaline infusion it was 405 ml./kg body weight.min. At rest about one tenth, and during noradrenaline infusion about one quarter of the cardiac output went to brown adipose tissue.
5. It was calculated that most of the extra oxygen consumed during the metabolic response of the anaesthetized new-born rabbit to noradrenaline infusion or cold exposure was consumed by brown adipose tissue.
6. Hypoxia (breathing 10% O2 in N2) greatly reduced the increase in oxygen consumption but not the increase in blood flow in brown adipose tissue caused by noradrenaline infusion.
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Selected References
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- ADAMSONS K., Jr Breathing and the thermal environment in young rabbits. J Physiol. 1959 Dec;149:144–153. doi: 10.1113/jphysiol.1959.sp006331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLATTEIS C. M. HYPOXIA AND THE METABOLIC RESPONSE TO COLD IN NEW-BORN RABBITS. J Physiol. 1964 Aug;172:358–368. doi: 10.1113/jphysiol.1964.sp007424. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BULLARD R. W., FUNKHOUSER G. E. Estimated regional blood flow by rubidium 86 distribution during arousal from hibernation. Am J Physiol. 1962 Aug;203:266–270. doi: 10.1152/ajplegacy.1962.203.2.266. [DOI] [PubMed] [Google Scholar]
- DAWES G. S., MESTYAN G. CHANGES IN THE OXYGEN CONSUMPTION OF NEW-BORN GUINEA-PIGS AND RABBITS ON EXPOSURE TO COLD. J Physiol. 1963 Aug;168:22–42. doi: 10.1113/jphysiol.1963.sp007176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAWKINS M. J., HULL D. BROWN ADIPOSE TISSUE AND THE RESPONSE OF NEW-BORN RABBITS TO COLD. J Physiol. 1964 Aug;172:216–238. doi: 10.1113/jphysiol.1964.sp007414. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAUSBERGER F. X., WIDELITZ M. M. Distribution of labeled erythrocytes in adipose tissue and muscle in the rat. Am J Physiol. 1963 Apr;204:649–652. doi: 10.1152/ajplegacy.1963.204.4.649. [DOI] [PubMed] [Google Scholar]
- HILL J. R. The oxygen consumption of new-born and adult mammals. Its dependence on the oxygen tension in the inspired air and on the environmental temperature. J Physiol. 1959 Dec;149:346–373. doi: 10.1113/jphysiol.1959.sp006344. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hull D., Segall M. M. The contribution of brown adipose tissue to heat production in the new-born rabbit. J Physiol. 1965 Dec;181(3):449–457. doi: 10.1113/jphysiol.1965.sp007773. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hull D. The structure and function of brown adipose tissue. Br Med Bull. 1966 Jan;22(1):92–96. doi: 10.1093/oxfordjournals.bmb.a070447. [DOI] [PubMed] [Google Scholar]
- MOORE R. E., UNDERWOOD M. C. Hexamethonium, hypoxia and heat production in new-born and infant kittens and puppies. J Physiol. 1962 Apr;161:30–53. doi: 10.1113/jphysiol.1962.sp006871. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SAPIRSTEIN L. A. Regional blood flow by fractional distribution of indicators. Am J Physiol. 1958 Apr;193(1):161–168. doi: 10.1152/ajplegacy.1958.193.1.161. [DOI] [PubMed] [Google Scholar]
- SCOPES J. W., TIZARD J. P. The effect of intravenous noradrenaline on the oxygen consumption of new-born mammals. J Physiol. 1963 Feb;165:305–326. doi: 10.1113/jphysiol.1963.sp007058. [DOI] [PMC free article] [PubMed] [Google Scholar]