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. 1967 Feb;188(3):425–434. doi: 10.1113/jphysiol.1967.sp008147

The effect of adrenaline and noradrenaline on hormone secretion and blood flow from the thyroid vein in sheep with exteriorized thyroids

I R Falconer
PMCID: PMC1396020  PMID: 4166301

Abstract

1. Emotional stimulus to the sheep has previously been shown to cause increased thyroid hormone secretion; the influence of adrenaline and noradrenaline in this process has been investigated.

2. Sheep bearing exteriorized thyroid glands on carotid artery—jugular vein loops were used. Thyroid vein blood was collected through a cannula in the jugular vein within the loop, and blood flow was measured by a plethysmographic technique.

3. 131I (50 μc) was injected intramuscularly (I.M.) into the sheep, and 4-7 days later the concentration of total and protein bound 131I in thyroid vein blood was measured in samples taken every 10 min for 4 hr. Intracarotid injections of 1 μg, I.V. injections of 5 μg, or I.V. infusions at 10 μg/min for 10 min, of adrenaline or noradrenaline were administered 1·5 hr after commencement of sampling. Blood flow from the thyroid was measured in similar experiments.

4. No significant changes in thyroid hormone secretion could be attributed to adrenaline or noradrenaline, and it was concluded that circulating catecholamines do not influence the release of thyroid hormone observed after brief emotional stimulus in the sheep.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACKERMAN N. B., ARONS W. L. The effect of epinephrine and norepinephrine on the acute thyroid release of thyroid hormones. Endocrinology. 1958 Jun;62(6):723–737. doi: 10.1210/endo-62-6-723. [DOI] [PubMed] [Google Scholar]
  2. ACLAND J. D. The estimation of serum protein-bound iodine by alkaline incineration. Biochem J. 1957 May;66(1):177–188. doi: 10.1042/bj0660177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. AMIRAGOVA M. G. Analysis of the hormonal and nervous means of exerting cerebral cortical regulatory influences on the thyroid gland. Gen Comp Endocrinol. 1961 Jun;1:91–102. doi: 10.1016/0016-6480(61)90037-5. [DOI] [PubMed] [Google Scholar]
  4. BROWN-GRANT K., GIBSON J. G. The effect of exogenous and endogenous adrenaline on the uptake of radio-iodine by the thyroid gland of the rabbit. J Physiol. 1956 Jan 27;131(1):85–101. doi: 10.1113/jphysiol.1956.sp005446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FALCONER I. R. EFFECTS OF FEAR AND ADRENALINE ON BLOOD FLOW FROM THE THYROID VEIN IN SHEEP WITH EXTERIORIZED THYROIDS. J Physiol. 1965 Mar;177:215–224. doi: 10.1113/jphysiol.1965.sp007587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FALCONER I. R., HETZEL B. S. EFFECT OF EMOTIONAL STRESS AND TSH ON THYROID VEIN HORMONE LEVEL IN SHEEP WITH EXTERIORIZED THYROIDS. Endocrinology. 1964 Jul;75:42–48. doi: 10.1210/endo-75-1-42. [DOI] [PubMed] [Google Scholar]
  7. HARRISON T. S. ADRENAL MEDULLARY AND THYROID RELATIONSHIPS. Physiol Rev. 1964 Apr;44:161–185. doi: 10.1152/physrev.1964.44.2.161. [DOI] [PubMed] [Google Scholar]
  8. Harrison T. S., Silver D. M., Zuidema G. D. Thyroid and adrenal medullary function in chronic "executive" monkeys. Endocrinology. 1966 Apr;78(4):685–689. doi: 10.1210/endo-78-4-685. [DOI] [PubMed] [Google Scholar]
  9. MOWBRAY J. F., PEART W. S. Effects of noradrenaline and adrenaline on the thyroid. J Physiol. 1960 May;151:261–271. doi: 10.1113/jphysiol.1960.sp006436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SCHNECKLOTH R. E., KURLAND G. S., FREEDBERG A. S. Effect of variation in thyroid function on the pressor response to norepinephrine in man. Metabolism. 1953 Nov;2(6):546–555. [PubMed] [Google Scholar]

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