Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1977 May;185(5):555–564. doi: 10.1097/00000658-197705000-00008

Chemotherapy of sarcomas of the limbs by regional perfusion.

E T Krementz, R D Carter, C M Sutherland, I Hutton
PMCID: PMC1396183  PMID: 266397

Abstract

From 1957 to 1975, 113 patients with sarcoma of the extremities have been treated with chemotherapy by regional perfusion, either alone or as an adjunct to excisional surgery. Perfusion alone in 54 patients was associated with an early response rate of 83%, but only four patients had complete regression of tumor for longer than three months. When perfusion was followed by immediate or delayed excision, better results were obtained. In 49 Stage I patients and in 24 Stage II patients, cumulative survivals of 66% and 59% were obtained at five years and 66% and 51% at 10 years. The procedure has also been useful in saving functional limbs by converting tumors to operability, and in the palliation of pain and ulceration.

Full text

PDF
555

Images in this article

557Fig. 2.
on p.557
557Fig. 3.
on p.557
560Figs. 5a and b.
on p.560

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CADMAN N. L., SOULE E. H., KELLY P. J. SYNOVIAL SARCOMA; AN ANALYSIS OF 34 TUMORS. Cancer. 1965 May;18:613–627. doi: 10.1002/1097-0142(196505)18:5<613::aid-cncr2820180510>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  2. CREECH O., Jr, KREMENTZ E. T., RYAN R. F., WINBLAD J. N. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958 Oct;148(4):616–632. doi: 10.1097/00000658-195810000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carter R. D., Krementz E. T. Chemotherapy of rhabdomyosarcoma by regional perfusion: a case report. Am Surg. 1976 Mar;42(3):212–214. [PubMed] [Google Scholar]
  4. Cavaliere R., Ciocatto E. C., Giovanella B. C., Heidelberger C., Johnson R. O., Margottini M., Mondovi B., Moricca G., Rossi-Fanelli A. Selective heat sensitivity of cancer cells. Biochemical and clinical studies. Cancer. 1967 Sep;20(9):1351–1381. doi: 10.1002/1097-0142(196709)20:9<1351::aid-cncr2820200902>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  5. Gerner R. E., Moore G. E., Pickren J. W. Soft tissue sarcomas. Ann Surg. 1975 Jun;181(6):803–808. doi: 10.1097/00000658-197506000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holton C. P., Chapman K. E., Lackey R. W., Hatch E. I., Baum E. S., Favara B. E. Extended combination therapy of childhood rhabdomyosarcoma. Cancer. 1973 Dec;32(6):1310–1316. doi: 10.1002/1097-0142(197312)32:6<1310::aid-cncr2820320603>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  7. KREMENTZ E. T., KNUDSON L. The effect of increased oxygen tension on the tumoricidal effect of nitrogen mustard. Surgery. 1961 Jul;50:266–273. [PubMed] [Google Scholar]
  8. Kempson R. L., Kyriakos M. Fibroxanthosarcoma of the soft tissues. A type of malignant fibrous histiocytoma. Cancer. 1972 Apr;29(4):961–976. doi: 10.1002/1097-0142(197204)29:4<961::aid-cncr2820290443>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  9. LEATHER R. P., ECKERT C. Hyperbaric oxygenation and mechlorethamine effectiveness. Arch Surg. 1963 Jul;87:144–147. doi: 10.1001/archsurg.1963.01310130146018. [DOI] [PubMed] [Google Scholar]
  10. Lindberg R. D., Martin R. G., Romsdahl M. M. Surgery and postoperative radiotherapy in the treatment of soft tissue sarcomas in adults. Am J Roentgenol Radium Ther Nucl Med. 1975 Jan;123(1):123–129. doi: 10.2214/ajr.123.1.123. [DOI] [PubMed] [Google Scholar]
  11. McBride C. M. Sarcomas of the limbs. Results of adjuvant chemotherapy using isolation perfusion. Arch Surg. 1974 Aug;109(2):304–308. doi: 10.1001/archsurg.1974.01360020164032. [DOI] [PubMed] [Google Scholar]
  12. Millar R. C., Ketcham A. S. The effect of heparin and warfarin on primary and metastatic tumors. J Med. 1974;5(1):23–31. [PubMed] [Google Scholar]
  13. SHIEBER W., GRAHAM P. An experience with sarcomas of the soft tissues in adults. Surgery. 1962 Aug;52:295–298. [PubMed] [Google Scholar]
  14. STEHLIN J. S., Jr, CLARK R. L., Jr, WHITE E. C., SMITH J. L., Jr, GRIFFIN A. C., JESSE R. H., Jr, HEALEY J. E., Jr Regional chemotherapy for cancer: experiences with 116 perfusions. Ann Surg. 1960 Apr;151:605–619. doi: 10.1097/00000658-196004000-00024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schraffordt Koops H., Eibergen R., Oldhoff J., van der Ploeg E., Vermey A. Isolated regional perfusion in the treatment of soft tissue sarcomas of the extremities. Clin Oncol. 1976 Sep;2(3):245–252. [PubMed] [Google Scholar]
  16. Shiu M. H., Castro E. B., Hajdu S. I., Fortner J. G. Surgical treatment of 297 soft tissue sarcomas of the lower extremity. Ann Surg. 1975 Nov;182(5):597–602. doi: 10.1097/00000658-197511000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Simon M. A., Enneking W. F. The management of soft-tissue sarcomas of the extremities. J Bone Joint Surg Am. 1976 Apr;58(3):317–327. [PubMed] [Google Scholar]
  18. Stehlin J. S., Jr Hyperthermic perfusion with chemotherapy for cancers of the extremities. Surg Gynecol Obstet. 1969 Aug;129(2):305–308. [PubMed] [Google Scholar]
  19. Suit H. D., Russell W. O., Martin R. G. Management of patients with sarcoma of soft tissue in an extremity. Cancer. 1973 May;31(5):1247–1255. doi: 10.1002/1097-0142(197305)31:5<1247::aid-cncr2820310533>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES