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. 1977 Jul;186(1):97–100. doi: 10.1097/00000658-197707000-00013

Comparison of the fecal microflora of Seventh-Day Adventists with individuals consuming a general diet. Implications concerning colonic carcinoma.

M J Goldberg, J W Smith, R L Nichols
PMCID: PMC1396198  PMID: 327955

Abstract

Qualitative and quantitative fecal microflora was studied in a double blind fashion in 28 subjects. Fourteen were Seventh-Day Adventists, who were strict vegetarians, while the remaining 14 subjects were individuals consuming a general western diet. No statistically significant differences were identified in the fecal microflora of the two groups. The bacteriologic analysis included total aerobes and total anaerobes as well as each of the major fecal aerobes and anaerobes. This study seems to indicate that the dietary intake of animal fat and protein does not significantly alter the fecal microflora, a possibility which has previously been suggested as being part of the explanation for the higher incidence of colonic carcinoma in those who consume meat compared with vegetarians. It does not, however, invalidate the concept that dietary animal fat does increase bile acid degradation within the gastrointestinal tract, a factor which has been related to colon cancer. Future studies should be directed at identifying the factors that may be present in the gastrointestinal tracts of vegetarians which modify the ability of their colonic microflora to degrade bile acids, an essential step in the production of intraluminal carcinogens or co-carcinogens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aries V., Crowther J. S., Drasar B. S., Hill M. J., Williams R. E. Bacteria and the aetiology of cancer of the large bowel. Gut. 1969 May;10(5):334–335. doi: 10.1136/gut.10.5.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BUELL P., DUNN J. E., Jr CANCER MORTALITY AMONG JAPANESE ISSEI AND NISEI OF CALIFORNIA. Cancer. 1965 May;18:656–664. doi: 10.1002/1097-0142(196505)18:5<656::aid-cncr2820180515>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  3. Burkitt D. P. Epidemiology of cancer of the colon and rectum. Cancer. 1971 Jul;28(1):3–13. doi: 10.1002/1097-0142(197107)28:1<3::aid-cncr2820280104>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  4. Coombs M. M., Bhatt T. S., Croft C. J. Correlation between carcinogenicity and chemical structure in cyclopenta(a)phenanthrenes. Cancer Res. 1973 Apr;33(4):832–837. [PubMed] [Google Scholar]
  5. Doll R. Worldwide distribution of gastrointestinal cancer. Natl Cancer Inst Monogr. 1967 Jul;25:173–190. [PubMed] [Google Scholar]
  6. Drasar B. S., Crowther J. S., Goddard P., Hawksworth G., Hill M. J., Peach S., Williams R. E., Renwick A. The relation between diet and the gut microflora in man. Proc Nutr Soc. 1973 Sep;32(2):49–52. doi: 10.1079/pns19730014. [DOI] [PubMed] [Google Scholar]
  7. Drasar B. S., Irving D. Environmental factors and cancer of the colon and breast. Br J Cancer. 1973 Feb;27(2):167–172. doi: 10.1038/bjc.1973.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gregor O., Toman R., Prusová F. Gastrointestinal cancer and nutrition. Gut. 1969 Dec;10(12):1031–1034. doi: 10.1136/gut.10.12.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HAENSZEL W., DAWSON E. A. A NOTE ON MORTALITY FROM CANCER OF THE COLON AND RECTUM IN THE UNITED STATES. Cancer. 1965 Mar;18:265–272. doi: 10.1002/1097-0142(196503)18:3<265::aid-cncr2820180302>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  10. Haenszel W., Correa P. Cancer of the colon and rectum and adenomatous polyps. A review of epidemiologic findings. Cancer. 1971 Jul;28(1):14–24. doi: 10.1002/1097-0142(197107)28:1<14::aid-cncr2820280105>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  11. Hill M. J. Bacteria and the etiology of colonic cancer. Cancer. 1974 Sep;34(3):suppl–suppl:818. doi: 10.1002/1097-0142(197409)34:3+<815::aid-cncr2820340705>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  12. Hill M. J., Drasar B. S. Degradation of bile salts by human intestinal bacteria. Gut. 1968 Feb;9(1):22–27. doi: 10.1136/gut.9.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. LEMON F. R., WALDEN R. T., WOODS R. W. CANCER OF THE LUNG AND MOUTH IN SEVENTH-DAY ADVENTISTS. PRELIMINARY REPORT ON A POPULATION STUDY. Cancer. 1964 Apr;17:486–497. doi: 10.1002/1097-0142(196404)17:4<486::aid-cncr2820170410>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  14. Reddy B. S., Wynder E. L. Large-bowel carcinogenesis: fecal constituents of populations with diverse incidence rates of colon cancer. J Natl Cancer Inst. 1973 Jun;50(6):1437–1442. doi: 10.1093/jnci/50.6.1437. [DOI] [PubMed] [Google Scholar]
  15. Staszewski J., Haenszel W. Cancer mortality among the Polish-born in the United States. J Natl Cancer Inst. 1965 Aug;35(2):291–297. [PubMed] [Google Scholar]
  16. Stemmermann G. N. Patterns of disease among Japanese living in Hawaii. Arch Environ Health. 1970 Feb;20(2):266–273. doi: 10.1080/00039896.1970.10665585. [DOI] [PubMed] [Google Scholar]
  17. WYNDER E. L., LEMON F. R., BROSS I. J. Cancer and coronary artery disease among Seventh-Day Adventists. Cancer. 1959 Sep-Oct;12:1016–1028. doi: 10.1002/1097-0142(195909/10)12:5<1016::aid-cncr2820120523>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  18. Walker A. R., Walker B. F., Richardson B. D. Bowel transit times in Bantu populations. Br Med J. 1970 Jul 4;3(5713):48–49. doi: 10.1136/bmj.3.5713.48-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wynder E. L., Kajitani T., Ishikawa S., Dodo H., Takano A. Environmental factors of cancer of the colon and rectum. II. Japanese epidemiological data. Cancer. 1969 May;23(5):1210–1220. doi: 10.1002/1097-0142(196905)23:5<1210::aid-cncr2820230530>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  20. Wynder E. L., Reddy B. S. Metabolic epidemiology of colorectal cancer. Cancer. 1974 Sep;34(3):suppl–suppl:806. doi: 10.1002/1097-0142(197409)34:3+<801::aid-cncr2820340703>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  21. Wynder E. L., Reddy B. Studies of large-bowel cancer: human leads to experimental application. J Natl Cancer Inst. 1973 May;50(5):1099–1106. doi: 10.1093/jnci/50.5.1099. [DOI] [PubMed] [Google Scholar]
  22. Wynder E. L., Shigematsu T. Environmental factors of cancer of the colon and rectum. Cancer. 1967 Sep;20(9):1520–1561. doi: 10.1002/1097-0142(196709)20:9<1520::aid-cncr2820200920>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]

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