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. 1977 Jan;185(1):128–131. doi: 10.1097/00000658-197701000-00021

Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study.

L H Toledo-Pereyra, R L Simmons, L C Olson, J S Najarian
PMCID: PMC1396251  PMID: 318820

Abstract

We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized, double-blind, prospective plan. There was no difference in the short-term or long-term function of either group of kidneys. Allopurinol does not appear to have as consistent a beneficial effect on non-ischemically damaged human kidneys as that observed experimentally on ischemically damaged canine organs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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