Abstract
Gastric ulceration developed in eight patients during intrahpeatic arterial infusion of 5-FU. Bleeding occurred in four instances and perforation in one. In all cases the catheter tip had been dislodged and was proximal to its correct position, allowing the stomach to be directly infused with 5-FU. No duodenal ulcers were noted. All patients were symptomatic for several days before the diagnosis was made. Of 20 patients with catheter dislodgement, five had documented ulcers, three had upper gastrointestinal bleeding of undetermined etiology, eight had epigastric pain or vomiting and only four were asymptomatic. Prompt determination of catheter position is necessary in patients receiving intrahepatic arterial infusion of 5-FU if symptoms consistent with gastric ulceration occur. Gastric ulcers should be vigorously treated because of the high rate of complications in patients receiving chemotherapy.
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- Ansfield F. J., Ramirez G., Davis H. L., Jr, Wirtanen G. W., Johnson R. O., Bryan G. T., Manalo F. B., Borden E. C., Davis T. E., Esmili M. Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil. Cancer. 1975 Dec;36(6 Suppl):2413–2417. doi: 10.1002/1097-0142(197512)36:6<2413::aid-cncr2820360621>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Ansfield F. J., Ramirez G., Skibba J. L., Bryan G. T., Davis H. L., Jr, Wirtanen G. W. Intrahepatic arterial infusion with 5-fluorouracil. Cancer. 1971 Nov;28(5):1147–1151. doi: 10.1002/1097-0142(1971)28:5<1147::aid-cncr2820280510>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
- Blumenthal I. S. Digestive disease as a national problem. 3. Social cost of peptic ulcer. Gastroenterology. 1968 Jan;54(1):86–92. [PubMed] [Google Scholar]
- Donaldson G. A., Jarrett F. Perforated gastroduodenal ulcer disease at the Massachusetts General Hospital from 1952 to 1970. Am J Surg. 1970 Sep;120(3):306–311. [PubMed] [Google Scholar]
- Gill A. M. Gastric ulcer. Br Med J. 1968 Aug 17;3(5615):415–418. doi: 10.1136/bmj.3.5615.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jordan G. L., Jr, Angel R. T., DeBakey M. E. Acute gastroduodenal perforation. Comparative study of treatment with simple closure, subtotal gastrectomy, and hemigastrectomy and vagotomy. Arch Surg. 1966 Apr;92(4):449–455. doi: 10.1001/archsurg.1966.01320220005002. [DOI] [PubMed] [Google Scholar]
- Kukral J. C. Gastric ulcer: an appraisal. Surgery. 1968 Jun;63(6):1024–1036. [PubMed] [Google Scholar]
- LARSON N. E., CAIN J. C., BARTHOLOMEW L. G. Prognosis of the medically treated small gastric ulcer. I. Comparison of follow-up data in two series. N Engl J Med. 1961 Jan 19;264:119–123. doi: 10.1056/NEJM196101192640304. [DOI] [PubMed] [Google Scholar]
- MACDONALD W. C., TRIER J. S., EVERETT N. B. CELL PROLIFERATION AND MIGRATION IN THE STOMACH, DUODENUM, AND RECTUM OF MAN: RADIOAUTOGRAPHIC STUDIES. Gastroenterology. 1964 Apr;46:405–417. [PubMed] [Google Scholar]