Abstract
The effect of systemic hypoxemia and hypovolemia on pulmonary fine structure was studied and compared in 12 Labrador puppies 6 days to 3 weeks old. Central venous and arterial pressures were monitored and arterial pH, PCO2 and PO2 recorded serially. In 4 puppies lung biopsies were taken after a two hour period of breathing 7% oxygen. Four other puppies were made hypovolemic by acute hemorrhage of 50% of the calculated blood volume and lung biopsies taken after one hour. Four control puppies were maintained under anesthesia for two hours, breathing an atmosphere of 20% oxygen before lung biopsies were taken. Both hypoxemia and hypovolemia resulted in similar pulmonary ultrastructural changes. These changes which occurred more frequently in areas where the air spaces and blood vessels were expanded, were characterized by aggregation of platelets and leucocytes in the vascular space, focal endothelial cell disruption, interstitial edema and type I epithelial cell discontinuities with exudation of plasma into the alveolar air spaces.
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- CHU J., CLEMENTS J. A., COTTON E., KLAUS M. H., SWEET A. Y., THOMAS M. A., TOOLEY W. H. PRELIMINARY REPORT. THE PULMONARY HYPOPERFUSION SYNDROME. Pediatrics. 1965 May;35:733–742. [PubMed] [Google Scholar]
- COHEN M. M., WEINTRAUB D. H., LILIENFELD A. M. The relationship of pulmonary hyaline membrane to certain factors in pregnancy and delivery. Pediatrics. 1960 Jul;26:42–50. [PubMed] [Google Scholar]
- Connell R. S., Swank R. L., Webb M. C. The development of pulmonary ultrastructural lesions during hemorrhagic shock. J Trauma. 1975 Feb;15(2):116–129. doi: 10.1097/00005373-197502000-00004. [DOI] [PubMed] [Google Scholar]
- DAWES G. S., MOTT J. C., WIDDICOMBE J. G., WYATT D. G. Changes in the lungs of the new-born lamb. J Physiol. 1953 Jul;121(1):141–162. doi: 10.1113/jphysiol.1953.sp004936. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harrison M. W., Connell R. S., Campbell J. R., Webb M. C. Microcirculatory changes in the gastrointestinal tract of the hypoxic puppy: an electron microscope study. J Pediatr Surg. 1975 Oct;10(5):599–608. doi: 10.1016/0022-3468(75)90362-0. [DOI] [PubMed] [Google Scholar]
- Harrison M. W., Connell R. S., Campbell J. R., Webb M. C. Pulmonary fine structural changes in children with tissue hypoxia. J Pediatr Surg. 1976 Oct;11(5):695–702. doi: 10.1016/0022-3468(76)90092-0. [DOI] [PubMed] [Google Scholar]
- Lauweryns J. M. "Hyaline membrane disease" in newborn infants. Macroscopic, radiographic, and light and electron microscopic studies. Hum Pathol. 1970 Jun;1(2):175–204. doi: 10.1016/s0046-8177(70)80033-8. [DOI] [PubMed] [Google Scholar]
- Rudolph A. M., Yuan S. Response of the pulmonary vasculature to hypoxia and H+ ion concentration changes. J Clin Invest. 1966 Mar;45(3):399–411. doi: 10.1172/JCI105355. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VAN BREEMEN V. L., NEUSTEIN H. B., BRUNS P. D. Pulmonary hyaline membranes studies with the electron microscope. Am J Pathol. 1957 Jul-Aug;33(4):769–789. [PMC free article] [PubMed] [Google Scholar]