Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1977 Mar;185(3):349–355. doi: 10.1097/00000658-197703000-00017

Evaluation of a new monkey model for the repeated study of bile secretory physiology.

R A Wood, A L Baker, A W Hall, J L Boyer, A R Moossa
PMCID: PMC1396621  PMID: 402891

Abstract

An unchaired monkey model for the repeated long-term study of biliary secretory physiology is reported. Postoperative management with cholre recorded. Evaluation was performed by repeated measurement, over a period of months, of bile flow and 14C erythritol clearance at three rates of taurocholate infusion given intravenously in a random order. Response to secretin was tested at the final infusion rate of taurocholate for each experiment. The outcomes of 9 monkeys were described of which 5 were repeatedly studied. They demonstrated an increase in bile flow and 14C erythritol clearance with increasing bile salt output. A dramatic choleresis over a wide range of bile salt excretion was noted with secretin and a linear relationship between bile bicarbonate output and bile salt secretion rate was observed. The new model has several major advantages and gives higher bile flows than previously recorded in the chaired model.

Full text

PDF
349

Images in this article

350Fig. 2.
on p.350
351Fig. 3.
on p.351

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARBER-RILEY G. MEASUREMENT OF CAPACITY OF BILIARY TREE IN RATS. Am J Physiol. 1963 Dec;205:1122–1126. doi: 10.1152/ajplegacy.1963.205.6.1122. [DOI] [PubMed] [Google Scholar]
  2. Boyer J. L. Canalicular bile formation in the isolated perfused rat liver. Am J Physiol. 1971 Oct;221(4):1156–1163. doi: 10.1152/ajplegacy.1971.221.4.1156. [DOI] [PubMed] [Google Scholar]
  3. Campbell C. B., Burgess P., Roberts S. A., Dowling R. H. The use of rhesus monkeys to study biliary secretion with an intact enterohepatic circulation. Aust N Z J Med. 1972 Feb;2(1):49–56. doi: 10.1111/j.1445-5994.1972.tb03908.x. [DOI] [PubMed] [Google Scholar]
  4. Dowling R. H., Mack E., Picott J., Berger J., Small D. M. Experimental model for the study of the enterohepatic circulation of bile in rhesus monkeys. J Lab Clin Med. 1968 Jul;72(1):169–176. [PubMed] [Google Scholar]
  5. Hall A. W., Moossa A. R., Clark J., Cooley G. R., Skinner D. B. The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man. Gut. 1975 May;16(5):347–352. doi: 10.1136/gut.16.5.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hardison W. G., Norman J. C. Electrolyte composition of the secretin fraction of bile from the perfused pig liver. Am J Physiol. 1968 Apr;214(4):758–763. doi: 10.1152/ajplegacy.1968.214.4.758. [DOI] [PubMed] [Google Scholar]
  7. Javitt N. B., Emerman S. Effect of sodium taurolithocholate on bile flow and bile acid exeretion. J Clin Invest. 1968 May;47(5):1002–1014. doi: 10.1172/JCI105790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Keighley M. R., Graham N. G. Infective cholecystitis. J R Coll Surg Edinb. 1973 Jul;18(4):213–220. [PubMed] [Google Scholar]
  9. Lynn J., Williams L., O'Brien J., Wittenberg J., Egdahl R. H. Effects of estrogen upon bile: implications with respect to gallstone formation. Ann Surg. 1973 Oct;178(4):514–524. doi: 10.1097/00000658-197310000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Moossa A. R., Hall A. W., Skinner D. B., Winans C. S. Effect of fifty percent small bowel resection on gastric secretory function in rhesus monkeys. Surgery. 1976 Aug;80(2):208–213. [PubMed] [Google Scholar]
  11. Strasberg S. M., Ilson R. G., Siminovitch K. A., Brenner D., Palaheimo J. E. Analysis of the components of bile flow in the rhesus monkey. Am J Physiol. 1975 Jan;228(1):115–121. doi: 10.1152/ajplegacy.1975.228.1.115. [DOI] [PubMed] [Google Scholar]
  12. Strasberg S. M., Ilson R. G. The effect of bile acid synthesis on cholesterol secretion into the bile. Ann Surg. 1975 Apr;181(4):458–465. doi: 10.1097/00000658-197504000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Strasberg S. M., Redinger R. N., Dorn B. C., Small D. M., Egdahl R. H. Effects of alteration of biliary pressure on bile composition--a method for study: primate biliary physiology. V. Gastroenterology. 1971 Sep;61(3):357–362. [PubMed] [Google Scholar]
  14. Wheeler H. O., Ross E. D., Bradley S. E. Canalicular bile production in dogs. Am J Physiol. 1968 Apr;214(4):866–874. doi: 10.1152/ajplegacy.1968.214.4.866. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES