Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1978 Aug;188(2):234–239. doi: 10.1097/00000658-197808000-00017

Clinical manifestations of infections with herpesviruses after kidney transplantation: a prospective study of various syndromes.

S Naraqi, O Jonasson, G G Jackson, H M Yamashiroya
PMCID: PMC1396739  PMID: 210727

Abstract

Herpesviruses infections occur commonly following kidney transplantation and immunosuppression, and contribute substantially to morbidity in the transplant recipient. In this prospective study, stomatitis, mononucleosis, hepatitis, or interstitial pneumonia occurred in 24 of 30 patients (80%) as a result of reactivation of latent herpesvirus infections, but the majority of these syndromes were self-limited and the infections were often asymptomatic. Rejection occurred significantly more frequently in CMV-infected patients, but a distinct causal relationship cannot be deduced.

Full text

PDF
234

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong D., Balakrishnan S. L., Steger L., Yu B., Stenzel K. H. Cytomegalovirus infections with viremia following renal transplantation. Arch Intern Med. 1971 Jan;127(1):111–115. [PubMed] [Google Scholar]
  2. Aston D. L., Cohen A., Spindler M. A. Herpesvirus hominis infection in patients with myeloproliferative and lymphoproliferative disorders. Br Med J. 1972 Nov 25;4(5838):462–465. doi: 10.1136/bmj.4.5838.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bone D., Wyllie R., Anderson N., Williams G. M. Cytomegalovirus infections in human renal transplants. Surg Forum. 1973;24:323–325. [PubMed] [Google Scholar]
  4. Briggs J. D., Timbury M. C., Paton A. M., Bell P. R. Viral infection and renal transplant rejection. Br Med J. 1972 Dec 2;4(5839):520–522. doi: 10.1136/bmj.4.5839.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Caldwell J. E., Porter D. D. Herpetic pneumonia in alcoholic hepatitis. JAMA. 1971 Sep 20;217(12):1703–1703. [PubMed] [Google Scholar]
  6. Corey L., Stamm W. E., Feorino P. M., Bryan J. A., Weseley S., Gregg M. B., Solangi K. HBs-Ag-negative hepatitis in a hemodialysis unit: relation to Epstein-Barr virus. N Engl J Med. 1975 Dec 18;293(25):1273–1278. doi: 10.1056/NEJM197512182932501. [DOI] [PubMed] [Google Scholar]
  7. Coulson A. S., Lucas Z. J., Condy M., Cohn R. Forty-day fever. An epidemic of cytomegalovirus disease in a renal transplant population. West J Med. 1974 Jan;120(1):1–7. [PMC free article] [PubMed] [Google Scholar]
  8. David D. S., Millian S. J., Whitsell J. C., Schwartz G. H., Riggio R. R., Stenzel K. H., Rubin A. L. Viral syndromes and renal homograft rejection. Ann Surg. 1972 Feb;175(2):257–259. doi: 10.1097/00000658-197202000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dorfman L. J. Cytomegalovirus encephalitis in adults. Neurology. 1973 Feb;23(2):136–144. doi: 10.1212/wnl.23.2.136. [DOI] [PubMed] [Google Scholar]
  10. Fauci A. S., Dale D. C., Balow J. E. Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med. 1976 Mar;84(3):304–315. doi: 10.7326/0003-4819-84-3-304. [DOI] [PubMed] [Google Scholar]
  11. Fiala M., Payne J. E., Berne T. V., Moore T. C., Henle W., Montgomerie J. Z., Chatterjee S. N., Guze L. B. Epidemiology of cytomegalovirus infection after transplantation and immunosuppression. J Infect Dis. 1975 Oct;132(4):421–433. doi: 10.1093/infdis/132.4.421. [DOI] [PubMed] [Google Scholar]
  12. HILL R. B., Jr, ROWLANDS D. T., Jr, RIFKIND D. INFECTIOUS PULMONARY DISEASE IN PATIENTS RECEIVING IMMUNOSUPPRESSIVE THERAPY FOR ORGAN TRANSPLANTATION. N Engl J Med. 1964 Nov 12;271:1021–1027. doi: 10.1056/NEJM196411122712001. [DOI] [PubMed] [Google Scholar]
  13. Ho M., Suwansirikul S., Dowling J. N., Youngblood L. A., Armstrong J. A. The transplanted kidney as a source of cytomegalovirus infection. N Engl J Med. 1975 Nov 27;293(22):1109–1112. doi: 10.1056/NEJM197511272932201. [DOI] [PubMed] [Google Scholar]
  14. Kanich R. E., Craighead J. E. Cytomegalovirus infection and cytomegalic inclusion disease in renal homotransplant recipients. Am J Med. 1966 Jun;40(6):874–882. doi: 10.1016/0002-9343(66)90202-6. [DOI] [PubMed] [Google Scholar]
  15. Lang D. J. Cytomegalovirus infections in organ transplantation and post transfusion. An hypothesis. Arch Gesamte Virusforsch. 1972;37(4):365–377. doi: 10.1007/BF01241460. [DOI] [PubMed] [Google Scholar]
  16. Lopez C., Simmons R. L., Mauer S. M., Najarian J. S., Good R. A., Gentry S. Association of renal allograft rejection with virus infections. Am J Med. 1974 Mar;56(3):280–289. doi: 10.1016/0002-9343(74)90609-3. [DOI] [PubMed] [Google Scholar]
  17. Luby J. P., Burnett W., Hull A. R., Ware A. J., Shorey J. W., Peters P. C. Relationship between cytomegalovirus and hepatic function abnormalities in the period after renal transplant. J Infect Dis. 1974 May;129(5):511–518. doi: 10.1093/infdis/129.5.511. [DOI] [PubMed] [Google Scholar]
  18. Montgomerie J. Z., Becroft D. M., Croxson M. C., Doak P. B., North J. D. Herpes-simplex-virus infection after renal transplantation. Lancet. 1969 Oct 25;2(7626):867–871. doi: 10.1016/s0140-6736(69)92327-7. [DOI] [PubMed] [Google Scholar]
  19. Myers B. D., Griffel B., Naveh D., Jankielowiiz T., Klajman A. Membrano-proliferative glomerulonephritis associated with persistent viral hepatitis. Am J Clin Pathol. 1973 Aug;60(2):222–228. doi: 10.1093/ajcp/60.2.222. [DOI] [PubMed] [Google Scholar]
  20. Naraqi S., Jackson G. G., Jonasson O. M. Viremia with herpes simplex type 1 in adults. Four nonfatal cases, one with features of chicken pox. Ann Intern Med. 1976 Aug;85(2):165–169. doi: 10.7326/0003-4819-85-2-165. [DOI] [PubMed] [Google Scholar]
  21. Naraqi S., Jackson G. G., Jonasson O., Yamashiroya H. M. Prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts. J Infect Dis. 1977 Oct;136(4):531–540. doi: 10.1093/infdis/136.4.531. [DOI] [PubMed] [Google Scholar]
  22. Payne J. E., Fiala M., Spencer M., Chatterjee S. N., Berne T. V. Cytomegalovirus antigen-antibody complexes in biopsy specimens in renal allograft rejection. Surg Forum. 1974;25(0):273–275. [PubMed] [Google Scholar]
  23. Pien F. D., Smith T. F., Anderson C. F., Webel M. L., Taswell H. F. Herpesviruses in renal transplant patients. Transplantation. 1973 Nov;16(5):489–495. doi: 10.1097/00007890-197311000-00014. [DOI] [PubMed] [Google Scholar]
  24. Reed W., Lucas Z. J., Kempson R., Cohn R. Renal transplantation in patients with Australia antigenemia. Transplant Proc. 1971 Mar;3(1):343–346. [PubMed] [Google Scholar]
  25. Rifkind D., Goodman N., Hill R. B., Jr The clinical significance of cytomegalovirus infection in renal transplant recipients. Ann Intern Med. 1967 Jun;66(6):1116–1128. doi: 10.7326/0003-4819-66-6-1116. [DOI] [PubMed] [Google Scholar]
  26. Simmons R. L., Lopez C., Balfour H., Jr, Kalis J., Rattazzi L. C., Najarian J. S. Cytomegalovirus: Clinical virological correlations in renal transplant recipients. Ann Surg. 1974 Oct;180(4):623–634. doi: 10.1097/00000658-197410000-00028. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Singer C., Armstrong D., Rosen P. P., Schottenfeld D. Pneumocystis carinii pneumonia: a cluster of eleven cases. Ann Intern Med. 1975 Jun;82(6):772–777. doi: 10.7326/0003-4819-82-6-722. [DOI] [PubMed] [Google Scholar]
  28. Spencer E. S., Andersen H. K. Antibodies to the Epstein-Barr virus in kidney transplant recipients. Acta Med Scand. 1972 Jan-Feb;191(1-2):107–110. [PubMed] [Google Scholar]
  29. Spencer E. S. Clinical aspects of cytomegalovirus infection in kidney-graft recipients. Scand J Infect Dis. 1974;6(4):315–323. doi: 10.3109/inf.1974.6.issue-4.04. [DOI] [PubMed] [Google Scholar]
  30. Strauch B., Andrews L. L., Siegel N., Miller G. Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressive drugs. Lancet. 1974 Feb 16;1(7851):234–237. doi: 10.1016/s0140-6736(74)92546-x. [DOI] [PubMed] [Google Scholar]
  31. Tilney N. L., Collins J. J., Jr, Wilson R. E. Hemorrhagic pancreatitis. A fatal complication of renal transplantation. N Engl J Med. 1966 May 12;274(19):1051–1057. doi: 10.1056/NEJM196605122741903. [DOI] [PubMed] [Google Scholar]
  32. Wu B. C., Dowling J. N., Armstrong J. A., Ho M. Enhancement of mouse cytomegalovirus infection during host-versus-graft reaction. Science. 1975 Oct 3;190(4209):56–58. doi: 10.1126/science.170676. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES