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. 1979 Jan;189(1):96–100. doi: 10.1097/00000658-197901000-00018

The functional importance of sympathetic nerves to the liver and endocrine pancreas.

J Järhult, B Falck, S Ingemansson, A Nobin
PMCID: PMC1396948  PMID: 365113

Abstract

Sympathetic noradrenergic nerves, with their wellknown cardiovascular effects, have recently been found to influence several metabolic and hormone-releasing processes. Morphological investigations in man have revealed a dense sympathetic innervation of the liver parenchyma as well as sympathetic fibers among the endocrine cells in the islets of Langerhans. Functional studies both in animals and man have shown that electrical or reflex activation of the hepatic and pancreatic sympathetic nerve fibers causes an increased output of glucose from the liver as well as a stimulation of glucagon and an inhibition of insulin release from the pancreas. From these results we conclude that damage to sympathetic nerves should be avoided in abdominal surgery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bloom S. R., Edwards A. V., Vaughan N. J. The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf. J Physiol. 1973 Sep;233(2):457–466. doi: 10.1113/jphysiol.1973.sp010317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CARLSSON A., FALCK B., HILLARP N. A. Cellular localization of brain monoamines. Acta Physiol Scand Suppl. 1962;56(196):1–28. [PubMed] [Google Scholar]
  3. Carey L. C., Lowery B. D., Cloutier C. T. Blood sugar and insulin response of humans in shock. Ann Surg. 1970 Sep;172(3):342–350. doi: 10.1097/00000658-197009000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coore H. G., Randle P. J. Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro. Biochem J. 1964 Oct;93(1):66–78. doi: 10.1042/bj0930066. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Edwards A. V., Silver M. Comparison of the hyperglycaemic and glycogenolytic responses to catecholamines with those to stimulation of the hepatic sympathetic innervation in the dog. J Physiol. 1972 Jun;223(2):571–593. doi: 10.1113/jphysiol.1972.sp009863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Edwards A. V. The hyperglycaemic response to stimulation of the hepatic sympathetic innervation in adrenalectomized cats and dogs. J Physiol. 1972 Feb;220(3):697–710. doi: 10.1113/jphysiol.1972.sp009730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Järhult J., Holst J. J. Stimulation of glucagon and inhibition of insulin secretion evoked from carotid baroreceptors. Experientia. 1977 Feb 15;33(2):236–237. doi: 10.1007/BF02124086. [DOI] [PubMed] [Google Scholar]
  8. Järhult J. Role of the symphato-adrenal system in hemorrhagic hyperglycemia. Acta Physiol Scand. 1975 Jan;93(1):25–33. doi: 10.1111/j.1748-1716.1975.tb05787.x. [DOI] [PubMed] [Google Scholar]
  9. Kaneto A., Kajinuma H., Kosaka K. Effect of splanchnic nerve stimulation on glucagon and insulin output in the dog. Endocrinology. 1975 Jan;96(1):143–150. doi: 10.1210/endo-96-1-143. [DOI] [PubMed] [Google Scholar]
  10. Lanciault G., Jacobson E. D. The gastrointestinal circulation. Gastroenterology. 1976 Nov;71(5):851–873. [PubMed] [Google Scholar]
  11. Lindsey C. A., Faloona G. R., Unger R. H. PLasma glucagon levels during rapid exsanguination with and without adrenergic blockade. Diabetes. 1975 Apr;24(4):313–316. [PubMed] [Google Scholar]
  12. Mellander S., Johansson B. Control of resistance, exchange, and capacitance functions in the peripheral circulation. Pharmacol Rev. 1968 Sep;20(3):117–196. [PubMed] [Google Scholar]
  13. Nobin A., Falck B., Ingemansson S., Järhult J., Rosengren E. Organization and function of the sympathetic innervation. Acta Physiol Scand Suppl. 1977;452:103–106. [PubMed] [Google Scholar]
  14. Porte D., Jr, Girardier L., Seydoux J., Kanazawa Y., Posternak J. Neural regulation of insulin secretion in the dog. J Clin Invest. 1973 Jan;52(1):210–214. doi: 10.1172/JCI107168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Robertson R. P., Porte D., Jr Adrenergic modulation of basal insulin secretion in man. Diabetes. 1973 Jan;22(1):1–8. doi: 10.2337/diab.22.1.1. [DOI] [PubMed] [Google Scholar]
  16. Shimazu T., Amakawa A. Regulation of glycogen metabolism in liver by the autonomic nervous system. II. Neural control of glycogenolytic enzymes. Biochim Biophys Acta. 1968 Oct 15;165(3):335–348. doi: 10.1016/0304-4165(68)90211-0. [DOI] [PubMed] [Google Scholar]
  17. Wilmore D. W., Moylan J. A., Jr, Lindsey C. A., Faloona G. R., Unger R. H., Pruitt B. A., Jr Hyperglucagonemia following thermal injury: insulin and glucagon in the posttraumatic catabolic state. Surg Forum. 1973;24:99–101. [PubMed] [Google Scholar]
  18. Woods S. C., Porte D., Jr Neural control of the endocrine pancreas. Physiol Rev. 1974 Jul;54(3):596–619. doi: 10.1152/physrev.1974.54.3.596. [DOI] [PubMed] [Google Scholar]

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