Abstract
Carcinoembryonic antigen (CEA) levels in the feces and serum were evaluated in 22 colorectal cancer patients and 20 healthy volunteers; in CEA levels gastric juice and serum were also evaluated in 28 gastric cancer patients and 14 peptic ulcer patients. Fecal CEA was found in all of 22 colorectal cancer patients as well as in the 20 healthy volunteers. Elevated fecal CEA levels were observed in the colorectal cancer patients, as compared to the healthy volunteers. The feces of 15 of the 22 colorectal cancer patients contained CEA at concentrations higher than the mean value plus twice the standard deviation of the healthy volunteers. The fecal CEA levels did not correlate directly either with Dukes' stage or serum CEA levels. CEA in gastric juice was elevated significantly in 26 of gastric cancer patients, with the exception of two patients with early gastric cancer. On the other hand, serum CEA was elevated in only nine of the 28 gastric cancer patients. These results point out the distinct value of assaying CEA in the feces or gastric juice as an aid in the diagnosis of colorectal or gastric cancer.
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- Burtin P., Chavanel G., Hirsch-Marie H. Characterization of a second normal antigen that cross-reacts with CEA. J Immunol. 1973 Dec;111(6):1926–1928. [PubMed] [Google Scholar]
- Burtin P., von Kleist S., Sabine M. C., King M. Immunohistological localization of carcinoembryonic antigen and nonspecific cross-reacting antigen in gastrointestinal normal and tumoral tissues. Cancer Res. 1973 Dec;33(12):3299–3305. [PubMed] [Google Scholar]
- Deutsch E., Apffel C. A., Mori H., Walker J. E. A tumor-associated antigen in gastric cancer secretions. Cancer Res. 1973 Jan;33(1):112–116. [PubMed] [Google Scholar]
- Egan M. L., Pritchard D. G., Todd C. W., Go V. L. Isolation and immunochemical and chemical characterization of carcinoembryonic antigen-like substances in colon lavages of healthy individuals. Cancer Res. 1977 Aug;37(8 Pt 1):2638–2643. [PubMed] [Google Scholar]
- Elias E. G., Holyoke E. D., Chu T. M. Carcinoembryonic antigen (CEA) in feces and plasma of normal subjects and patients with colorectal carcinoma. Dis Colon Rectum. 1974 Jan-Feb;17(1):38–41. doi: 10.1007/BF02587533. [DOI] [PubMed] [Google Scholar]
- Freed D. L., Taylor G. Carcinoembryonic antigen in faeces. Br Med J. 1972 Jan 8;1(5792):85–87. doi: 10.1136/bmj.1.5792.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOLD P., FREEDMAN S. O. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. J Exp Med. 1965 Mar 1;121:439–462. doi: 10.1084/jem.121.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hirai H. A collaborative clinical study of carcinoembryonic antigen in Japan. Cancer Res. 1977 Jul;37(7 Pt 1):2267–2274. [PubMed] [Google Scholar]
- Livingstone A. S., Hampson L. G., Shuster J., Gold P., Hinchey E. J. Carcinoembryonic antigen in the diagnosis and management of colorectal carcinoma. Current status. Arch Surg. 1974 Aug;109(2):259–264. doi: 10.1001/archsurg.1974.01360020119023. [DOI] [PubMed] [Google Scholar]
- Loewenstein M. S., Zamcheck N. Carcinoembryonic antigen and the liver. Gastroenterology. 1977 Jan;72(1):161–166. [PubMed] [Google Scholar]
- Molnar I. G., Vandevoorde J. P., Gitnick G. L. CEA levels in fluids bathing gastrointestinal tumors. Gastroenterology. 1976 Apr;70(4):513–515. [PubMed] [Google Scholar]
- Moore T., Dhar P., Zamcheck N., Keeley A., Gottlieb L., Kupchik H. Z. Carcinoembryonic antigen(s) in liver disease. I. Clinical and morphological studies. Gastroenterology. 1972 Jul;63(1):88–94. [PubMed] [Google Scholar]
- Pusztaszeri G., Mach J. P. Carcinoembryonic antigen (CEA) in non digestive cancerous and normal tissues. Immunochemistry. 1973 Mar;10(3):197–204. doi: 10.1016/0019-2791(73)90008-6. [DOI] [PubMed] [Google Scholar]
- Shuster J., Silverman M., Gold P. Metabolism of human carcinoembryonic antigen in xenogeneic animals. Cancer Res. 1973 Jan;33(1):65–68. [PubMed] [Google Scholar]
- Stevens D. P., Mackay I. R. Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet. 1973 Dec 1;2(7840):1238–1239. doi: 10.1016/s0140-6736(73)90975-6. [DOI] [PubMed] [Google Scholar]
- Sugarbaker P. H. Carcinoembryonic antigen (CEA) assays in obstructive colorectal cancer. Ann Surg. 1976 Dec;184(6):752–757. doi: 10.1097/00000658-197612000-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vuento M., Ruoslahti E., Pihko H., Svenberg T., Ihamäki T., Siurala M. Carcinoembryonic antigen-like substance in gastric juice. Immunochemistry. 1976 Apr;13(4):313–316. doi: 10.1016/0019-2791(76)90340-2. [DOI] [PubMed] [Google Scholar]