Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1978 Dec;188(6):791–796. doi: 10.1097/00000658-197812000-00013

Effects of protein depletion and repletion on cell-mediated immunity in experimental animals.

J M Daly, S J Dudrick, E M Copeland
PMCID: PMC1396997  PMID: 104668

Abstract

Protein-calorie malnutrition leads to depression of host cell-mediated immunity. Nutritional repletion initially results in rapid weight gain followed by a more gradual return of immunocompetence. Administration of a synthetic amino acid diet to normal animals did not preserve body weight or cell-mediated immunity any better than did a high carbohydrate, protein-free diet. Administration of a synthetic amino acid diet to malnourished animals maintained body weight, but did not restore immunocompetence. Proper nutritional repletion should provide both adequate protein and nonprotein calories if a return of immunocompetence is to be anticipated.

Full text

PDF
791

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aschkenasy A. Effect of a protein-free diet on lymph node and spleen cell response in vivo to blastogenic stimulants. Nature. 1975 Mar 6;254(5495):63–65. doi: 10.1038/254063a0. [DOI] [PubMed] [Google Scholar]
  2. Bistrian B. R., Blackburn G. L., Scrimshaw N. S., Flatt J. P. Cellular immunity in semistarved states in hospitalized adults. Am J Clin Nutr. 1975 Oct;28(10):1148–1155. doi: 10.1093/ajcn/28.10.1148. [DOI] [PubMed] [Google Scholar]
  3. Brown R. E., Katz M. Passive transfer of delayed hypersensitivity reaction to tuberculin in children with protein calorie malnutrition. J Pediatr. 1967 Jan;70(1):126–128. doi: 10.1016/s0022-3476(67)80178-1. [DOI] [PubMed] [Google Scholar]
  4. Chandra R. K. Immunocompetence in undernutrition. J Pediatr. 1972 Dec;81(6):1194–1200. doi: 10.1016/s0022-3476(72)80262-2. [DOI] [PubMed] [Google Scholar]
  5. Cooper W. C., Good R. A., Mariani T. Effects of protein insufficiency on immune responsiveness. Am J Clin Nutr. 1974 Jun;27(6):647–664. doi: 10.1093/ajcn/27.6.647. [DOI] [PubMed] [Google Scholar]
  6. Copeland E. M., Fadyen B. V., Jr, Dudrick S. J. Effect of intravenous hyperalimentation on established delayed hypersensitivity in the cancer patient. Ann Surg. 1976 Jul;184(1):60–64. doi: 10.1097/00000658-197607000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Edelman R., Suskind R., Olson R. E., Sirisinha S. Mechanisms of defective delayed cutaneous hypersensitivity in children with protein-calorie malnutrition. Lancet. 1973 Mar 10;1(7802):506–508. doi: 10.1016/s0140-6736(73)90326-7. [DOI] [PubMed] [Google Scholar]
  8. Geefhuysen J., Rosen E. U., Katz J., Ipp T., Metz J. Impaired cellular immunity in kwashiorkor with improvement after therapy. Br Med J. 1971 Nov 27;4(5786):527–529. doi: 10.1136/bmj.4.5786.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Harland P. S. Tuberculin reactions in malnourished children. Lancet. 1965 Oct 9;2(7415):719–721. doi: 10.1016/s0140-6736(65)90457-5. [DOI] [PubMed] [Google Scholar]
  10. Jose D. G., Good R. A. Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice. J Exp Med. 1973 Jan 1;137(1):1–9. doi: 10.1084/jem.137.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jose D. G., Good R. A. Quantitative effects of nutritional protein and calorie deficiency upon immune responses to tumors in mice. Cancer Res. 1973 Apr;33(4):807–812. [PubMed] [Google Scholar]
  12. Law D. K., Dudrick S. J., Abdou N. I. Immunocompetence of patients with protein-calorie malnutrition. The effects of nutritional repletion. Ann Intern Med. 1973 Oct;79(4):545–550. doi: 10.7326/0003-4819-79-4-545. [DOI] [PubMed] [Google Scholar]
  13. Lloyd A. V. Tuberculin test in children with malnutrition. Br Med J. 1968 Aug 31;3(5617):529–531. doi: 10.1136/bmj.3.5617.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McFarlane H., Hamid J. Cell-mediated immune response in malnutrition. Clin Exp Immunol. 1973 Jan;13(1):153–164. [PMC free article] [PubMed] [Google Scholar]
  15. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  16. Woodruff J. F., Kilbourne E. D. The influence of quantitated post-weaning undernutrition on coxsackievirus B3 infection of adult mice. I. Viral persistence and increased severity of lesions. J Infect Dis. 1970 Feb;121(2):137–163. doi: 10.1093/infdis/121.2.137. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES