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. 1978 Dec;188(6):778–782. doi: 10.1097/00000658-197812000-00011

Muscle blood flow following thermal injury.

L H Aulick, D W Wilmore, A D Mason Jr, B A Pruitt Jr
PMCID: PMC1397005  PMID: 736656

Abstract

Peripheral circulation is markedly increased during the hyperdynamic-hypermetabolic phase of thermal injury and appears to be directed primarily to the burn wound. To determine whether any portion of this extra blood flow reaches another major peripheral vascular bed, blood flow in the tibialis anterior muscle of the lower leg was measured by 133Xe clearance in ten hemodynamically stable, nonseptic burn patients (mean burn size = 42.5% total body surface) and five control subjects. Muscle blood flow was 3.52 +/- 0.26 ml/100 g.min (mean +/- S.E.M.) in these patients and 3.29 +/- 0.24 in controls, indicating that resting muscle perfusion was unaffected by the extent of total body surface injury, size of leg burn, or elevated rectal temperature (38.2 +/- 0.2 degrees C) of the patients. These results confirm the interpretations of previous studies suggesting that most of the increased peripheral blood flow following thermal injury is directed to the surface wound. Local and systemic factors responsible for the maintenance of muscle perfusion in the face of alterations in muscle metabolism following thermal injury are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amery A., Bossaert H., Verstraete M. Muscle blood flow in normal and hypertensive subjects. Influence of age, exercise, and body position. Am Heart J. 1969 Aug;78(2):211–216. doi: 10.1016/0002-8703(69)90010-6. [DOI] [PubMed] [Google Scholar]
  2. Aulick L. H., Wilmore D. W., Mason A. D., Jr, Pruitt B. A., Jr Influence of the burn wound on peripheral circulation in thermally injured patients. Am J Physiol. 1977 Oct;233(4):H520–H526. doi: 10.1152/ajpheart.1977.233.4.H520. [DOI] [PubMed] [Google Scholar]
  3. Finley R. J., Duff J. H., Holliday R. L., Jones D., Marchuk J. B. Capillary muscle blood flow in human sepsis. Surgery. 1975 Jul;78(1):87–94. [PubMed] [Google Scholar]
  4. Gump F. E., Price J. B., Jr, Kinney J. M. Blood flow and oxygen consumption in patients with severe burns. Surg Gynecol Obstet. 1970 Jan;130(1):23–28. [PubMed] [Google Scholar]
  5. Heistad D. D., Abboud F. M. Factors that influence blood flow in skeletal muscle and skin. Anesthesiology. 1974 Aug;41(2):139–156. doi: 10.1097/00000542-197408000-00005. [DOI] [PubMed] [Google Scholar]
  6. KONTOS H. A., SHAPIRO W., MAUCK H. P., Jr, RICHARDSON D. W., PATTERSON J. L., Jr, SHARPE A. R., Jr MECHANISM OF CERTAIN ABNORMALITIES OF THE CIRCULATION TO THE LIMBS IN THYROTOXICOSIS. J Clin Invest. 1965 Jun;44:947–956. doi: 10.1172/JCI105212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LASSEN N. A., LINDBJERG J., MUNCK O. MEASUREMENT OF BLOOD-FLOW THROUGH SKELETAL MUSCLE BY INTRAMUSCULAR INJECTION OF XENON-133. Lancet. 1964 Mar 28;1(7335):686–689. doi: 10.1016/s0140-6736(64)91518-1. [DOI] [PubMed] [Google Scholar]
  8. Rowell L. B. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev. 1974 Jan;54(1):75–159. doi: 10.1152/physrev.1974.54.1.75. [DOI] [PubMed] [Google Scholar]
  9. Russell H. E., Hartford C. E., Boyd W. C., Barnes R. W. Muscle blood flow in circumferentially burned extremities. Surg Forum. 1975;26:71–73. [PubMed] [Google Scholar]
  10. Wilmore D. W., Aulick L. H., Mason A. D., Pruitt B. A., Jr Influence of the burn wound on local and systemic responses to injury. Ann Surg. 1977 Oct;186(4):444–458. doi: 10.1097/00000658-197710000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wilmore D. W., Long J. M., Mason A. D., Jr, Skreen R. W., Pruitt B. A., Jr Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg. 1974 Oct;180(4):653–669. doi: 10.1097/00000658-197410000-00031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wilmore D. W., Mason A. D., Jr, Johnson D. W., Pruitt B. A., Jr Effect of ambient temperature on heat production and heat loss in burn patients. J Appl Physiol. 1975 Apr;38(4):593–597. doi: 10.1152/jappl.1975.38.4.593. [DOI] [PubMed] [Google Scholar]
  13. Wilmore D. W., Orcutt T. W., Mason A. D., Jr, Pruitt B. A. Alterations in hypothalamic function following thermal injury. J Trauma. 1975 Aug;15(8):697–703. doi: 10.1097/00005373-197508000-00012. [DOI] [PubMed] [Google Scholar]

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