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. 1979 Feb;189(2):209–216. doi: 10.1097/00000658-197902000-00013

100 HLA-identical sibling transplants. Prognostic factors other than histocompatibility.

N L Ascher, R L Simmons, H Noreen, J VanHook, R J Howard, D E Sutherland, J S Najarian
PMCID: PMC1397029  PMID: 371556

Abstract

Analysis of 100 patients receiving HLA identical sibling transplants was performed. Excellent graft survival demonstrated in the group attests to the importance of matching serological determined antigens. There seems to be a modest beneficial effect on antilymphoblast globulin in low dosage, but not in high doses. Insulin dependent diabetes mellitus results in a significant negative influence on patient survival and graft function in the male recipient but not in the female. A particularly striking point that emerges is the potential hazard in incorrectly treating for rejection. Rejection occurs very rarely in these patients; in a patient with deteriorating renal function, etiologies other than rejection should be vigorously sought (including transcutaneous biopsy) prior to initiation of rejection therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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