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. 1985 Sep;20(3):219–223. doi: 10.1111/j.1365-2125.1985.tb05064.x

Selectivity and dose-dependency of the inhibitory effect of propranolol on theophylline metabolism in man.

J O Miners, L M Wing, K J Lillywhite, R A Robson
PMCID: PMC1400697  PMID: 4041342

Abstract

The effects of separate 5 day pretreatments of propranolol 120 mg day-1 and 720 mg day-1 on theophylline clearance and metabolism at steady-state were determined in seven healthy males. Propranolol 120 mg day-1 decreased theophylline plasma clearance (CL) by 30%. Clearance of theophylline to each metabolite was reduced by this treatment, clearances to the two demethylated products by 42-43% and clearance to the 8-hydroxylation product by 27%. Propranolol 720 mg day-1 decreased theophylline CL by 52%. Again, clearance of theophylline to each metabolite was reduced by this treatment, clearances to the two demethylation products by 73-77% and clearance to the 8-hydroxylation product by 44%. These data are consistent with a dose-dependent and selective inhibitory effect of propranolol on the separate forms of cytochrome P-450 involved in theophylline demethylation and 8-hydroxylation.

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Selected References

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