Abstract
1 Anti-ischaemic effects and safety of nicardipine were assessed in 14 patients with vasospastic angina using a placebo comparison, cross-over design study for 8-13 weeks.
2 The average daily dose of nicardipine for optimal angina prevention was 84 mg (range 40-160 mg).
3 Nicardipine administration, as compared with placebo, significantly reduced anginal frequency and nitroglycerin consumption during the single- and double-blind phases of the study.
4 Nicardipine appears to be effective in the prevention of vasospastic angina and not to cause major adverse effects.
Keywords: calcium blockers, coronary spasm, dihydropyridine derivatives, rest angina
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Selected References
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