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. 1985;20(Suppl 1):178S–186S. doi: 10.1111/j.1365-2125.1985.tb05162.x

Nicardipine for stable angina pectoris

S Scheidt, M M Lewinter, J Hermanovich, K Venkataraman, D Freedman
PMCID: PMC1400796  PMID: 3927958

Abstract

1 Nicardipine, 30 and 40 mg thrice daily, was administered to 66 patients with stable angina pectoris in a multicentre, randomised, double-blind, cross-over trial.

2 With nicardipine therapy, duration of exercise and cumulative oxygen consumption increased, while times to onset of angina and 1 mm ST segment depression were prolonged.

3 Anginal frequency and nitroglycerin consumption declined with use of nicardipine, but this did not reach statistical significance.

4 Resting heart rate increased slightly and resting blood pressure decreased.

5 Two patients on nicardipine and one on placebo sustained acute infarction. Otherwise, side effects were generally mild and transient.

Keywords: nicardipine, placebo comparison, stable angina, treadmill exercise

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Selected References

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