Abstract
The influence of information on drug plasma monitoring during long-term antidepressant therapy in fourteen ambulant, depressed patients was evaluated as variation in the L/D ratio time course. A larger variability in L/D ratio, with higher coefficient of variation and a poorer clinical outcome, was found in non-informed patients. The data support the hypothesis that verbal information on long-term drug monitoring of antidepressants could improve patients' adherence to therapy.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Altamura A. C., Melorio T., Invernizzi G., Gomeni R. Influence of age on mianserin pharmacokinetics. Psychopharmacology (Berl) 1982;78(4):380–382. doi: 10.1007/BF00433747. [DOI] [PubMed] [Google Scholar]
- Ley P. Satisfaction, compliance and communication. Br J Clin Psychol. 1982 Nov;21(Pt 4):241–254. doi: 10.1111/j.2044-8260.1982.tb00562.x. [DOI] [PubMed] [Google Scholar]
- Loo H., Benyacoub A. K., Rovei V., Altamura C. A., Vadrot M., Morselli P. L. Long-term monitoring of tricyclic antidepressant plasma concentrations. Br J Psychiatry. 1980 Nov;137:444–451. doi: 10.1192/bjp.137.5.444. [DOI] [PubMed] [Google Scholar]
- Morris L. A., Halperin J. A. Effects of written drug information on patient knowledge and compliance: a literature review. Am J Public Health. 1979 Jan;69(1):47–52. doi: 10.2105/ajph.69.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Myers E. D., Calvert E. J. Information, compliance and side-effects: a study of patients on antidepressant medication. Br J Clin Pharmacol. 1984 Jan;17(1):21–25. doi: 10.1111/j.1365-2125.1984.tb04993.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rovei V., Sanjuan M., Hrdina P. D. Analysis of tricyclic antidepressant drugs by gas chromatography using nitrogen-selective detection with packed and capillary columns. J Chromatogr. 1980 Jun 13;182(3-4):349–357. doi: 10.1016/s0378-4347(00)81484-x. [DOI] [PubMed] [Google Scholar]
- Taves D. R. Minimization: a new method of assigning patients to treatment and control groups. Clin Pharmacol Ther. 1974 May;15(5):443–453. doi: 10.1002/cpt1974155443. [DOI] [PubMed] [Google Scholar]