Abstract
The effect of chloroquine on paracetamol kinetics and disposition was investigated in six healthy male Ghanaian volunteers. Chloroquine administration shortened the time taken to reach peak plasma paracetamol concentration (tmax) in five of the volunteers. Peak plasma paracetamol concentration (Cmax) was significantly increased by chloroquine administration. The area under the plasma paracetamol concentration-time curve was also significantly increased by chloroquine administration. There was, however, no effect of chloroquine on paracetamol metabolism.
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Selected References
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- Adriaenssens P. I., Prescott L. F. High performance liquid chromatographic estimation of paracetamol metabolites in plasma. Br J Clin Pharmacol. 1978 Jul;6(1):87–88. doi: 10.1111/j.1365-2125.1978.tb01687.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clements J. A., Heading R. C., Nimmo W. S., Prescott L. F. Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther. 1978 Oct;24(4):420–431. doi: 10.1002/cpt1978244420. [DOI] [PubMed] [Google Scholar]
- Varga F. Intestinal absorption of chloroquine in rats. Arch Int Pharmacodyn Ther. 1966 Sep;163(1):38–46. [PubMed] [Google Scholar]