Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1985 Oct;20(4):327–331. doi: 10.1111/j.1365-2125.1985.tb05072.x

A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects.

J W Rigby, A K Scott, G M Hawksworth, J C Petrie
PMCID: PMC1400877  PMID: 2866783

Abstract

Six elderly patients with established hypertension and six young healthy subjects were studied after 8 days of treatment with atenolol 50 mg day-1, metoprolol 50 mg day-1, oxprenolol 80 mg day-1 and propranolol 80 mg day-1. The area under the blood concentration-time curve was increased in the elderly group for each drug, but the difference was statistically significant only for atenolol. The lower serum albumin concentrations in the elderly group did not result in a decrease in the percentage of propranolol or oxprenolol bound to serum proteins.

Full text

PDF
327

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barber H. E., Hawksworth G. M., Kitteringham N. R., Petersen J., Petrie J. C., Swann J. M. Protein binding of atenolol and propranolol to human serum albumin and in human plasma [proceedings]. Br J Clin Pharmacol. 1978 Nov;6(5):446P–447P. [PubMed] [Google Scholar]
  2. Belpaire F. M., Bogaert M. G., Rosseneu M. Binding of beta-adrenoceptor blocking drugs to human serum albumin, to alpha 1-acid glycoprotein and to human serum. Eur J Clin Pharmacol. 1982;22(3):253–256. doi: 10.1007/BF00545224. [DOI] [PubMed] [Google Scholar]
  3. Castleden C. M., George C. F. The effect of ageing on the hepatic clearance of propranolol. Br J Clin Pharmacol. 1979 Jan;7(1):49–54. doi: 10.1111/j.1365-2125.1979.tb00896.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Castleden C. M., Kaye C. M., Parsons R. L. The effect of age on plasma levels of propranolol and practolol in man. Br J Clin Pharmacol. 1975 Aug;2(4):303–306. doi: 10.1111/j.1365-2125.1975.tb02774.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Degen P. H., Riess W. Simplified method for the determination of oxprenolol and other beta-receptor-blocking agents in biological fluids by gas-liquid chromatography. J Chromatogr. 1976 Jun 9;121(1):72–75. doi: 10.1016/s0021-9673(00)82299-2. [DOI] [PubMed] [Google Scholar]
  6. Di Salle E., Baker K. M., Bareggi S. R., Watkins W. D., Chidsey C. A., Frigerio A., Morselli P. L. A sensitive gas chromatographic method for the determination of propranolol in human plasma. J Chromatogr. 1973 Sep 26;84(2):347–353. doi: 10.1016/s0021-9673(01)91714-5. [DOI] [PubMed] [Google Scholar]
  7. Dillon N., Chung S., Kelly J., O'Malley K. Age and beta adrenoceptor-mediated function. Clin Pharmacol Ther. 1980 Jun;27(6):769–772. doi: 10.1038/clpt.1980.108. [DOI] [PubMed] [Google Scholar]
  8. Harries J. D., Mildenberger R. R., Malowany A. S., Drummond K. N. A computerized cummulative integral method for the precise measurement of the glomerular filtration rate. 1. Proc Soc Exp Biol Med. 1972 Sep;140(4):1148–1155. doi: 10.3181/00379727-140-36630. [DOI] [PubMed] [Google Scholar]
  9. Ishizaki T., Hirayama H., Tawara K., Nakaya H., Sato M., Sato K. Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: a study using sotalol as a model drug. J Pharmacol Exp Ther. 1980 Jan;212(1):173–181. [PubMed] [Google Scholar]
  10. Jusko W. J. Influence of cigarette smoking on drug metabolism in man. Drug Metab Rev. 1979;9(2):221–236. doi: 10.3109/03602537908993892. [DOI] [PubMed] [Google Scholar]
  11. Kendall M. J., Quarterman C. P. The effect of age on the pharmacokinetics of oxprenolol. Int J Clin Pharmacol Ther Toxicol. 1982 Mar;20(3):101–104. [PubMed] [Google Scholar]
  12. Pantuck E. J., Hsiao K. C., Maggio A., Nakamura K., Kuntzman R., Conney A. H. Effect of cigarette smoking on phenacetin metabolism. Clin Pharmacol Ther. 1974 Jan;15(1):9–17. doi: 10.1002/cpt19741519. [DOI] [PubMed] [Google Scholar]
  13. Piafsky K. M., Borgå O. Plasma protein binding of basic drugs. II. Importance of alpha 1-acid glycoprotein for interindividual variation. Clin Pharmacol Ther. 1977 Nov;22(5 Pt 1):545–549. doi: 10.1002/cpt1977225part1545. [DOI] [PubMed] [Google Scholar]
  14. Quarterman C. P., Kendall M. J., Jack D. B. The effect of age on the pharmacokinetics of metoprolol and its metabolites. Br J Clin Pharmacol. 1981 Mar;11(3):287–294. doi: 10.1111/j.1365-2125.1981.tb00536.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Regårdh C. G., Borg K. O., Johansson R., Johnsson G., Palmer L. Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man. J Pharmacokinet Biopharm. 1974 Aug;2(4):347–364. doi: 10.1007/BF01061407. [DOI] [PubMed] [Google Scholar]
  16. Regårdh C. G., Landahl S., Larsson M., Lundborg P., Steen B., Hoffmann K. J., Lagerström P. O. Pharmacokinetics of metoprolol and its metabolite alpha-OH-metoprolol in healthy, non-smoking, elderly individuals. Eur J Clin Pharmacol. 1983;24(2):221–226. doi: 10.1007/BF00613821. [DOI] [PubMed] [Google Scholar]
  17. Rubin P. C., Scott P. J., McLean K., Pearson A., Ross D., Reid J. L. Atenolol disposition in young and elderly subjects. Br J Clin Pharmacol. 1982 Feb;13(2):235–237. doi: 10.1111/j.1365-2125.1982.tb01364.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Scales B., Copsey P. B. The gas chromatographic determination of atenolol in biological samples. J Pharm Pharmacol. 1975 Jun;27(6):430–433. doi: 10.1111/j.2042-7158.1975.tb09473.x. [DOI] [PubMed] [Google Scholar]
  19. Schneider R. E., Bishop H., Yates R. A., Quarterman C. P., Kendall M. J. Effect of age on plasma propranolol levels. Br J Clin Pharmacol. 1980 Aug;10(2):169–171. doi: 10.1111/j.1365-2125.1980.tb01736.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vestal R. E., Wood A. J., Branch R. A., Shand D. G., Wilkinson G. R. Effects of age and cigarette smoking on propranolol disposition. Clin Pharmacol Ther. 1979 Jul;26(1):8–15. doi: 10.1002/cpt19792618. [DOI] [PubMed] [Google Scholar]
  21. Vestal R. E., Wood A. J., Shand D. G. Reduced beta-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther. 1979 Aug;26(2):181–186. doi: 10.1002/cpt1979262181. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES