Abstract
Colour discrimination was assessed by means of the Farnsworth-Munsell 100-Hue test in 54 patients being treated for tuberculosis with ethambutol and 50 patients who were treated for tuberculosis by drugs other than ethambutol. The ethambutol group showed significantly more errors than controls along the deuteran axis. The sub-group of ethambutol treated patients who had been taking the drug for more than 2 months showed significantly more errors along the tritan axis. It is concluded that subclinical colour discrimination impairment is relatively common in patients receiving ethambutol and that a deuteran type of defect is an early and a tritan type of defect is a later manifestation of ethambutol toxicity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aronson J. K., Ford A. R. The use of colour vision measurement in the diagnosis of digoxin toxicity. Q J Med. 1980;49(195):273–282. [PubMed] [Google Scholar]
- Delacoux E., Moreau Y., Godefroy A., Evstigneeff T. Prévention de la toxicité oculaire de l'éthambutol: intérêt de la zincémie et de l'analyse du sens chromatique. J Fr Ophtalmol. 1978 Mar;1(3):191–196. [PubMed] [Google Scholar]
- Pahlitzsch H., Tiburtius H. Augenuntersuchungen bei Behandlung mit dem neuen Tuberkulostatikum Ethambutol-dihydrochlorid Lederle (Myambutol) Klin Monbl Augenheilkd. 1969 Feb;154(2):228–232. [PubMed] [Google Scholar]
- Rietbrock N., Alken R. G. Color vision deficiencies: a common sign of intoxication in chronically digoxin-treated patients. J Cardiovasc Pharmacol. 1980 Jan-Feb;2(1):93–99. [PubMed] [Google Scholar]
- Schmidt I. G. Central nervous system effects of ethambutol in monkeys. Ann N Y Acad Sci. 1966 Apr 20;135(2):759–774. doi: 10.1111/j.1749-6632.1966.tb45521.x. [DOI] [PubMed] [Google Scholar]
- van Dijk B. W., Spekreijse H. Ethambutol changes the color coding of carp retinal ganglion cells reversibly. Invest Ophthalmol Vis Sci. 1983 Jan;24(1):128–133. [PubMed] [Google Scholar]