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. 1986 Apr;21(4):409–416. doi: 10.1111/j.1365-2125.1986.tb05215.x

Quantitation of dose and concentration-effect relationships for fenclofenac in rheumatoid arthritis.

F M Dunagan, P E McGill, A W Kelman, B Whiting
PMCID: PMC1400933  PMID: 3518772

Abstract

Response to non-steroidal anti-inflammatory drugs (NSAIDs) is not usually assessed on the basis of concentration measurements: identification of a concentration-effect relationship has proved difficult to achieve. Dose and concentration-effect relationships of fenclofenac have been determined in a group of 18 patients with rheumatoid arthritis at three dose levels (600, 1200 and 1800 mg day-1). The study was double-blind and treatments were randomised according to a Latin square design. A multiple linear regression technique (GLIM) was used in the analysis. The best model to describe the change in effect in terms of dose and concentration incorporated an average slope and an individual subject intercept for each effect measurement. On average, an improvement in grip strength of 20 mm Hg could be obtained with an increase in fenclofenac (trough) concentration of 100 micrograms ml-1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brooks P. M., Walker J. J., Dick W. C. Phenylbutazone: a clinico-pharmacological study in rheumatoid arthritis. Br J Clin Pharmacol. 1975 Oct;2(5):437–442. doi: 10.1111/j.1365-2125.1975.tb00553.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Capell H. A., Konetschnik B., Glass R. C. Anti-inflammatory analgesic drug responders and non-responders: a clinico-pharmacological study of flurbiprofen. Br J Clin Pharmacol. 1977 Oct;4(5):623–624. doi: 10.1111/j.1365-2125.1977.tb00797.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Day R. O., Furst D. E., Dromgoole S. H., Kamm B., Roe R., Paulus H. E. Relationship of serum naproxen concentration to efficacy in rheumatoid arthritis. Clin Pharmacol Ther. 1982 Jun;31(6):733–740. doi: 10.1038/clpt.1982.103. [DOI] [PubMed] [Google Scholar]
  4. Ekstrand R., Alván G., L'e Orme M., Lewander R., Palmér L., Sarby B. Double-blind dose-response study of indomethacin in rheumatoid arthritis. Eur J Clin Pharmacol. 1980 Jun;17(6):437–442. doi: 10.1007/BF00570161. [DOI] [PubMed] [Google Scholar]
  5. Grennan D. M., Aarons L., Siddiqui M., Richards M., Thompson R., Higham C. Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findings. Br J Clin Pharmacol. 1983 Mar;15(3):311–316. doi: 10.1111/j.1365-2125.1983.tb01504.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Huskisson E. C., Woolf D. L., Balme H. W., Scott J., Franklin S. Four new anti-inflammatory drugs: responses and variations. Br Med J. 1976 May 1;1(6017):1048–1049. doi: 10.1136/bmj.1.6017.1048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jones R. W. Benoxaprofen and its effect on serum alkaline phosphatase: a review. Eur J Rheumatol Inflamm. 1982;5(2):216–223. [PubMed] [Google Scholar]
  8. Nielsen-Kudsk F. HPLC-determination of some antiinflammatory, weak analgesic and uricosuric drugs in human blood plasma and its application to pharmacokinetics. Acta Pharmacol Toxicol (Copenh) 1980 Oct;47(4):267–273. doi: 10.1111/j.1600-0773.1980.tb03653.x. [DOI] [PubMed] [Google Scholar]
  9. Orme M., Baber N., Keenan J., Halliday L., Sibeon R., Littler T. Pharmacokinetics and biochemical effects in responders and non-responders to non-steroidal anti-inflammatory drugs. Scand J Rheumatol Suppl. 1981;39:19–27. doi: 10.3109/03009748109095330. [DOI] [PubMed] [Google Scholar]
  10. Orme M., Holt P. J., Hughes G. R., Bulpitt C. J., Draffan G. H., Thorgeirsson S. S., Williams F., Davies D. S. Plasma concentration of phenylbutazone and its therapeutic effect-studies in patients with rheumatoid arthritis. Br J Clin Pharmacol. 1976 Feb;3(1):185–191. doi: 10.1111/j.1365-2125.1976.tb00587.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  12. Scott D. L., Roden S., Marshall T., Kendall M. J. Variations in responses to non-steroidal anti-inflammatory drugs. Br J Clin Pharmacol. 1982 Nov;14(5):691–694. doi: 10.1111/j.1365-2125.1982.tb04958.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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