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. 1986 Apr;21(4):445–449. doi: 10.1111/j.1365-2125.1986.tb05220.x

Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children.

S Levene, S A McKenzie
PMCID: PMC1400938  PMID: 3518775

Abstract

The bronchial responsiveness of a group of asthmatic children was studied using histamine stimulation after a single dose of theophylline and after placebo. Theophylline, when levels were greater than 10 micrograms ml-1 significantly reduced responsiveness but only by just over one doubling concentration of histamine (P less than 0.001).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes P. J. Nocturnal asthma: mechanisms and treatment. Br Med J (Clin Res Ed) 1984 May 12;288(6428):1397–1398. doi: 10.1136/bmj.288.6428.1397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benson M. K. Bronchial provocation tests. Br J Clin Pharmacol. 1979 Nov;8(5):417–424. doi: 10.1111/j.1365-2125.1979.tb01020.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bierman C. W., Shapiro G. G., Pierson W. E., Dorsett C. S. Acute and chronic theophylline therapy in exercise-induced bronchospasm. Pediatrics. 1977 Dec;60(6):845–849. [PubMed] [Google Scholar]
  4. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. doi: 10.1111/j.1365-2222.1977.tb01448.x. [DOI] [PubMed] [Google Scholar]
  5. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Protective effect of drugs on histamine-induced asthma. Thorax. 1977 Aug;32(4):429–437. doi: 10.1136/thx.32.4.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fairfax A. J., McNabb W. R., Davies H. J., Spiro S. G. Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels. Thorax. 1980 Jul;35(7):526–530. doi: 10.1136/thx.35.7.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Falliers C. J. Assessment of oral antiasthmatic drugs by inhalation challenges. J Allergy Clin Immunol. 1979 Dec;64(6 Pt 2):685–688. doi: 10.1016/0091-6749(79)90039-3. [DOI] [PubMed] [Google Scholar]
  8. Hambleton G., Weinberger M., Taylor J., Cavanaugh M., Ginchansky E., Godfrey S., Tooley M., Bell T., Greenberg S. Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study. Lancet. 1977 Feb 19;1(8008):381–385. doi: 10.1016/s0140-6736(77)92601-0. [DOI] [PubMed] [Google Scholar]
  9. Hargreave F. E., Ryan G., Thomson N. C., O'Byrne P. M., Latimer K., Juniper E. F., Dolovich J. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol. 1981 Nov;68(5):347–355. doi: 10.1016/0091-6749(81)90132-9. [DOI] [PubMed] [Google Scholar]
  10. Hariparsad D., Wilson N., Dixon C., Silverman M. Reproducibility of histamine challenge tests in asthmatic children. Thorax. 1983 Apr;38(4):258–260. doi: 10.1136/thx.38.4.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Henry R. L., Mellis C. M., South R. T., Simpson S. J. Comparison of peak expiratory flow rate and forced expiratory volume in one second in histamine challenge studies in children. Br J Dis Chest. 1982 Apr;76(2):167–170. [PubMed] [Google Scholar]
  12. Juniper E. F., Frith P. A., Hargreave F. E. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax. 1981 Aug;36(8):575–579. doi: 10.1136/thx.36.8.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rachelefsky G. S., Katz R. M., Siegel S. C. A sustained release theophylline preparation: efficacy in childhood asthma with low serum theophylline levels. Ann Allergy. 1978 Apr;40(4):252–257. [PubMed] [Google Scholar]
  14. Ryan G., Dolovich M. B., Obminski G., Cockcroft D. W., Juniper E., Hargreave F. E., Newhouse M. T. Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation. J Allergy Clin Immunol. 1981 Feb;67(2):156–161. doi: 10.1016/0091-6749(81)90012-9. [DOI] [PubMed] [Google Scholar]
  15. Weinberger M. M., Bronsky E. A. Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children. J Pediatr. 1974 Mar;84(3):421–427. doi: 10.1016/s0022-3476(74)80732-8. [DOI] [PubMed] [Google Scholar]
  16. Wilson N., Silverman M. Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid? Br Med J (Clin Res Ed) 1982 Mar 20;284(6319):863–866. doi: 10.1136/bmj.284.6319.863. [DOI] [PMC free article] [PubMed] [Google Scholar]

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