Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1986 Apr;21(4):393–400. doi: 10.1111/j.1365-2125.1986.tb05213.x

The haemodynamic and myocardial effects of dopexamine: a new beta 2-adrenoceptor and dopaminergic agonist.

B E Jaski, W Wijns, R Foulds, P W Serruys
PMCID: PMC1400939  PMID: 2871852

Abstract

Dopexamine increases inotropic state and rate of relaxation independent of changes in heart rate. Dopexamine has a chronotropic effect and results in a decrease in systemic vascular resistance. Dopexamine has a spectrum of action that should be useful in patients with severe heart failure.

Full text

PDF
393

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bourdillon P. D., Dawson J. R., Foale R. A., Timmis A. D., Poole-Wilson P. A., Sutton G. C. Salbutamol in treatment of heart failure. Br Heart J. 1980 Feb;43(2):206–210. doi: 10.1136/hrt.43.2.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brower R. W., Meij S., Serruys P. W. A model of asynchronous left ventricular relaxation predicting the bi-exponential pressure decay. Cardiovasc Res. 1983 Aug;17(8):482–488. doi: 10.1093/cvr/17.8.482. [DOI] [PubMed] [Google Scholar]
  3. Brown R. A., Dixon J., Farmer J. B., Hall J. C., Humphries R. G., Ince F., O'Connor S. E., Simpson W. T., Smith G. W. Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors. Br J Pharmacol. 1985 Jul;85(3):599–608. doi: 10.1111/j.1476-5381.1985.tb10554.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown R. A., Farmer J. B., Hall J. C., Humphries R. G., O'Connor S. E., Smith G. W. The effects of dopexamine on the cardiovascular system of the dog. Br J Pharmacol. 1985 Jul;85(3):609–619. doi: 10.1111/j.1476-5381.1985.tb10555.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Canepa-Anson R., Dawson J. R., Frankl W. S., Kuan P., Sutton G. C., Reuben S., Poole-Wilson P. A. Beta 2 adrenoceptor agonists. Pharmacology, metabolic effects and arrhythmias. Eur Heart J. 1982 Dec;3 (Suppl 500):129–134. [PubMed] [Google Scholar]
  6. Goldberg L. I. Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev. 1972 Mar;24(1):1–29. [PubMed] [Google Scholar]
  7. Goldberg L. I., Hsieh Y. Y., Resnekov L. Newer catecholamines for treatment of heart failure and shock: an update on dopamine and a first look at dobutamine. Prog Cardiovasc Dis. 1977 Jan-Feb;19(4):327–340. doi: 10.1016/0033-0620(77)90007-x. [DOI] [PubMed] [Google Scholar]
  8. Goldberg L. I., Kohli J. D. Peripheral pre- and post-synaptic dopamine receptors: are they different from dopamine receptors in the central nervous system? Commun Psychopharmacol. 1979;3(6):447–456. [PubMed] [Google Scholar]
  9. Hedberg A., Minneman K. P., Molinoff P. B. Differential distribution of beta-1 and beta-2 adrenergic receptors in cat and guinea-pig heart. J Pharmacol Exp Ther. 1980 Mar;212(3):503–508. [PubMed] [Google Scholar]
  10. Heitz A., Schwartz J., Velly J. Beta-adrenoceptors of the human myocardium: determination of beta 1 and beta 2 subtypes by radioligand binding. Br J Pharmacol. 1983 Dec;80(4):711–717. doi: 10.1111/j.1476-5381.1983.tb10062.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Karliner J. S., LeWinter M. M., Mahler F., Engler R., O'Rourke R. A. Pharmacologic and hemodynamic influences on the rate of isovolumic left ventricular relaxation in the normal conscious dog. J Clin Invest. 1977 Sep;60(3):511–521. doi: 10.1172/JCI108803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kebabian J. W., Calne D. B. Multiple receptors for dopamine. Nature. 1979 Jan 11;277(5692):93–96. doi: 10.1038/277093a0. [DOI] [PubMed] [Google Scholar]
  13. Leier C. V., Unverferth D. V. Drugs five years later. Dobutamine. Ann Intern Med. 1983 Oct;99(4):490–496. doi: 10.7326/0003-4819-99-4-490. [DOI] [PubMed] [Google Scholar]
  14. Mahler F., Yoran C., Ross J., Jr Intropic effect of tachycardia and poststimulation potentiation in the conscious dog. Am J Physiol. 1974 Sep;227(3):569–575. doi: 10.1152/ajplegacy.1974.227.3.569. [DOI] [PubMed] [Google Scholar]
  15. Meester G. T., Bernard N., Zeelenberg C., Brower R. W., Hugenholtz P. G. A computer system for real time analysis of cardiac catheterization data. Cathet Cardiovasc Diagn. 1975;1(2):113–132. doi: 10.1002/ccd.1810010203. [DOI] [PubMed] [Google Scholar]
  16. O'Donnell S. R., Wanstall J. C. pA2 values of selective beta-adrenoceptor antagonists on isolated atria demonstrate a species difference in the beta-adrenoceptor populations mediating chronotropic responses in cat and guinea-pig. J Pharm Pharmacol. 1979 Oct;31(10):686–690. doi: 10.1111/j.2042-7158.1979.tb13629.x. [DOI] [PubMed] [Google Scholar]
  17. Quinones M. A., Gaasch W. H., Alexander J. K. Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man. Circulation. 1976 Feb;53(2):293–302. doi: 10.1161/01.cir.53.2.293. [DOI] [PubMed] [Google Scholar]
  18. Richard C., Ricome J. L., Rimailho A., Bottineau G., Auzepy P. Combined hemodynamic effects of dopamine and dobutamine in cardiogenic shock. Circulation. 1983 Mar;67(3):620–626. doi: 10.1161/01.cir.67.3.620. [DOI] [PubMed] [Google Scholar]
  19. Sharma B., Goodwin J. F. Beneficial effect of salbutamol on cardiac function in severe congestive cardiomyopathy. Effect on systolic and diastolic function of the left ventricle. Circulation. 1978 Sep;58(3 Pt 1):449–460. doi: 10.1161/01.cir.58.3.449. [DOI] [PubMed] [Google Scholar]
  20. Thompson D. S., Waldron C. B., Juul S. M., Naqvi N., Swanton R. H., Coltart D. J., Jenkins B. S., Webb-Peploe M. M. Analysis of left ventricular pressure during isovolumic relaxation in coronary artery disease. Circulation. 1982 Apr;65(4):690–697. doi: 10.1161/01.cir.65.4.690. [DOI] [PubMed] [Google Scholar]
  21. Weiss J. L., Frederiksen J. W., Weisfeldt M. L. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest. 1976 Sep;58(3):751–760. doi: 10.1172/JCI108522. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES