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. 1986;22(Suppl 2):125S–128S. doi: 10.1111/j.1365-2125.1986.tb02993.x

The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat

R Garrett, B Manthey, B Vernon-Roberts, P M Brooks
PMCID: PMC1400970  PMID: 3620271

Abstract

1 Anti-inflammatory effects of isoxicam alone and in combination with aspirin were studied in rats using the polyurethane sponge implantation model of acute inflammation.

2 Dose-response studies were performed to delineate a suppressive (high) and non-suppressive (low) dose of isoxicam prior to studying these doses in combination with aspirin.

3 The results indicate that a combination of aspirin with isoxicam does not have an additive anti-inflammatory effect.

4 The interference demonstrated by aspirin with the anti-inflammatory effects of other NSAIDs such as indomethacin is also demonstrated with aspirin/isoxicam combinations.

Keywords: isoxicam, interaction, acute inflammation, aspirin

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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