Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1986 May;21(5):533–536. doi: 10.1111/j.1365-2125.1986.tb02838.x

Transient bradycardia and subsequent sinus tachycardia produced by intravenous adenosine in healthy adult subjects.

A H Watt, P A Routledge
PMCID: PMC1401035  PMID: 3718811

Abstract

Adenosine was administered in increasing intravenous bolus doses to nine healthy volunteers. A transient decrease in heart rate was observed which occurred about 20 s after injection. This was due to a reduction in sinus rate and/or transient block of conduction through the atrioventricular node, and lasted less than 10 s. An increase in sinus rate which followed any transient bradycardia was also observed. The maximum bradycardia and maximum tachycardia were each significantly related to the logarithm of adenosine dose.

Full text

PDF
533

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belardinelli L., Belloni F. L., Rubio R., Berne R. M. Atrioventricular conduction disturbances during hypoxia. Possible role of adenosine in rabbit and guinea pig heart. Circ Res. 1980 Nov;47(5):684–691. doi: 10.1161/01.res.47.5.684. [DOI] [PubMed] [Google Scholar]
  2. Belardinelli L., Shryock J., West G. A., Clemo H. F., DiMarco J. P., Berne R. M. Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts. Circulation. 1984 Dec;70(6):1083–1091. doi: 10.1161/01.cir.70.6.1083. [DOI] [PubMed] [Google Scholar]
  3. Berne R. M., DiMarco J. P., Belardinelli L. Dromotropic effects of adenosine and adenosine antagonists in the treatment of cardiac arrhythmias involving the atrioventricular node. Circulation. 1984 Jun;69(6):1195–1197. doi: 10.1161/01.cir.69.6.1195. [DOI] [PubMed] [Google Scholar]
  4. DE BURGH DALY M., SCOTT M. J. An analysis of the primary cardiovascular reflex effects of stimulation of the carotid body chemoreceptors in the dog. J Physiol. 1962 Aug;162:555–573. doi: 10.1113/jphysiol.1962.sp006950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DE DALY M. B., SCOTT M. J. The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog. J Physiol. 1958 Nov 10;144(1):148–166. doi: 10.1113/jphysiol.1958.sp006092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DiMarco J. P., Sellers T. D., Berne R. M., West G. A., Belardinelli L. Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia. Circulation. 1983 Dec;68(6):1254–1263. doi: 10.1161/01.cir.68.6.1254. [DOI] [PubMed] [Google Scholar]
  7. Drury A. N., Szent-Györgyi A. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol. 1929 Nov 25;68(3):213–237. doi: 10.1113/jphysiol.1929.sp002608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Edlund A., Berglund B., van Dorne D., Kaijser L., Nowak J., Patrono C., Sollevi A., Wennmalm A. Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation. Circulation. 1985 Jun;71(6):1113–1120. doi: 10.1161/01.cir.71.6.1113. [DOI] [PubMed] [Google Scholar]
  9. Fox A. C., Reed G. E., Glassman E., Kaltman A. J., Silk B. B. Release of adenosine from human hearts during angina induced by rapid atrial pacing. J Clin Invest. 1974 May;53(5):1447–1457. doi: 10.1172/JCI107693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Klabunde R. E. Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol. 1983 Sep 16;93(1-2):21–26. doi: 10.1016/0014-2999(83)90026-2. [DOI] [PubMed] [Google Scholar]
  11. Munoz A., Leenhardt A., Sassine A., Galley P., Puech P. Therapeutic use of adenosine for terminating spontaneous paroxysmal supraventricular tachycardia. Eur Heart J. 1984 Sep;5(9):735–738. doi: 10.1093/oxfordjournals.eurheartj.a061734. [DOI] [PubMed] [Google Scholar]
  12. Szentmiklósi A. J., Németh M., Szegi J., Papp J. G., Szekeres L. Effect of adenosine on sinoatrial and ventricular automaticity of the guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):147–149. doi: 10.1007/BF00510253. [DOI] [PubMed] [Google Scholar]
  13. Watt A. H., Routledge P. A. Adenosine stimulates respiration in man. Br J Clin Pharmacol. 1985 Nov;20(5):503–506. doi: 10.1111/j.1365-2125.1985.tb05108.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Watt A. H. Sick sinus syndrome: an adenosine-mediated disease. Lancet. 1985 Apr 6;1(8432):786–788. doi: 10.1016/s0140-6736(85)91449-7. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES