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. 1986;22(Suppl 3):313S–318S.

Effects of intracoronary nicardipine and nifedipine on left ventricular function and coronary sinus blood flow

C A Visser, J J Koolen, H B van Wezel, R Jonges, G Hoedemaker, A J Dunning
PMCID: PMC1401053

Abstract

1 To determine the relative effects of nifedipine and nicardipine on left ventricular inotropy we directly injected into the left main coronary artery, in 12 patients with coronary artery disease, 20 min apart and in random order, 0.2 mg of each drug, which had previously been shown to increase coronary sinus blood flow equally. All variables were recorded at time (min), 1 through 5 and 7.5 and 10 min after injection.

2 Coronary sinus blood flow was increased by both drugs to the same extent (54% vs 56%).

3 Peak (+) and peak (-) dP/dt, and (dP/dt)/DP40 were affected by both drugs after 1 min, but by nifedipine to a significantly larger extent (P < 0.001, P < 0.001 and P < 0.005 respectively).

4 Left ventricular end-diastolic pressure was also increased by both drugs, but again was more pronounced after nifedipine (79% vs 30%, P < 0.001).

5 Left ventricular systolic pressure, mean aortic pressure and pulmonary artery pressure were not affected by nicardipine in contrast to nifedipine.

6 At doses that increased coronary sinus blood flow to a similar extent, nicardipine, in contrast to nifedipine, showed little effect on left ventricular inotropy.

Keywords: nicardipine, nifedipine, intracoronary, left ventricular function, coronary, sinus blood flow

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amlie J. P., Landmark K. The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Acta Pharmacol Toxicol (Copenh) 1978 Apr;42(4):287–291. doi: 10.1111/j.1600-0773.1978.tb02203.x. [DOI] [PubMed] [Google Scholar]
  2. Fleckenstein A. Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Annu Rev Pharmacol Toxicol. 1977;17:149–166. doi: 10.1146/annurev.pa.17.040177.001053. [DOI] [PubMed] [Google Scholar]
  3. Fleckenstein A., Tritthart H., Döring H. J., Byon K. Y. BAY a 1040--ein hochaktiver Ca -antagonistischer Inhibitor der elektro-mechanischen Koppelungsprozesse im Warmblüter-Myokard. Arzneimittelforschung. 1972 Jan;22(1):22–33. [PubMed] [Google Scholar]
  4. Ganz W., Tamura K., Marcus H. S., Donoso R., Yoshida S., Swan H. J. Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation. 1971 Aug;44(2):181–195. doi: 10.1161/01.cir.44.2.181. [DOI] [PubMed] [Google Scholar]
  5. Haeusler G. Differential effect of verapamil on excitation-contraction coupling in smooth muscle and on excitation-secretion coupling in adrenergic nerve terminals. J Pharmacol Exp Ther. 1972 Mar;180(3):672–682. [PubMed] [Google Scholar]
  6. Hashimoto K., Taira N., Chiba S., Hashimoto K., Jr, Endo M. Cardiohemodynamic effects of BAY a 1040 in the dog. Arzneimittelforschung. 1972 Jan;22(1):15–21. [PubMed] [Google Scholar]
  7. Hung J., Lamb I. H., Connolly S. J., Jutzy K. R., Goris M. L., Schroeder J. S. The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study. Circulation. 1983 Sep;68(3):560–567. doi: 10.1161/01.cir.68.3.560. [DOI] [PubMed] [Google Scholar]
  8. Mangiardi L. M., Hariman R. J., McAllister R. G., Jr, Bhargava V., Surawicz B., Shabetai R. Electrophysiologic and hemodynamic effects of verapamin. Correlation with plasma drug concentrations. Circulation. 1978 Feb;57(2):366–372. doi: 10.1161/01.cir.57.2.366. [DOI] [PubMed] [Google Scholar]
  9. Pouleur H., Etienne J., Van Mechelen H., Van Eyll C., Charlier A. A., Brasseur L. A., Rousseau M. F. Effects of nicardipine or nifedipine added to propranolol in patients with coronary artery disease. Postgrad Med J. 1984;60 (Suppl 4):23–28. [PubMed] [Google Scholar]
  10. Rousseau M. F., Veriter C., Detry J. M., Brasseur L., Pouleur H. Impaired early left ventricular relaxation in coronary artery disease: effects of intracornary nifedipine. Circulation. 1980 Oct;62(4):764–772. doi: 10.1161/01.cir.62.4.764. [DOI] [PubMed] [Google Scholar]
  11. Serruys P. W., Brower R. W., ten Katen H. J., Bom A. H., Hugenholtz P. G. Regional wall motion from radiopaque markers after intravenous and intracoronary injections of nifedipine. Circulation. 1981 Mar;63(3):584–591. doi: 10.1161/01.cir.63.3.584. [DOI] [PubMed] [Google Scholar]
  12. Serruys P. W., van den Brand M., Brower R. W., Hugenholtz P. G. Regional cardioplegia and cardioprotection during transluminal angioplasty, which role for nifedipine? Eur Heart J. 1983 May;4 (Suppl 100):115–121. doi: 10.1093/eurheartj/4.suppl_c.115. [DOI] [PubMed] [Google Scholar]
  13. Stone P. H., Antman E. M., Muller J. E., Braunwald E. Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications. Ann Intern Med. 1980 Dec;93(6):886–904. doi: 10.7326/0003-4819-93-6-886. [DOI] [PubMed] [Google Scholar]
  14. Vater W., Kroneberg G., Hoffmeister F., Saller H., Meng K., Oberdorf A., Puls W., Schlossmann K., Stoepel K. Zur Pharmakologie von 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredimethylester (Nifedipine), BAY a 1040. Arzneimittelforschung. 1972 Jan;22(1):1–14. [PubMed] [Google Scholar]
  15. Visser C. A., Jaarsma W., Kan G., Koolen J. J., Lie K. I. Immediate and long-term effects of nicardipine, at rest and during exercise, in patients with coronary artery disease. Br J Clin Pharmacol. 1985;20 (Suppl 1):158S–162S. doi: 10.1111/j.1365-2125.1985.tb05159.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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