Abstract
Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting. In a randomised double-blind trial it was found that oral lamotrigine (240 mg) was more effective than placebo, but less effective than diazepam (20 mg) in suppressing interictal spikes. Further clinical evaluation of lamotrigine is recommended in patients with epilepsy.
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Selected References
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- Mandelli M., Tognoni G., Garattini S. Clinical pharmacokinetics of diazepam. Clin Pharmacokinet. 1978 Jan-Feb;3(1):72–91. doi: 10.2165/00003088-197803010-00005. [DOI] [PubMed] [Google Scholar]
- Milligan N., Dhillon S., Oxley J., Richens A. Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG. Epilepsia. 1982 Jun;23(3):323–331. doi: 10.1111/j.1528-1157.1982.tb06198.x. [DOI] [PubMed] [Google Scholar]
- Milligan N., Oxley J., Richens A. Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man. Br J Clin Pharmacol. 1983 Sep;16(3):285–289. doi: 10.1111/j.1365-2125.1983.tb02163.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Gier J. J., 't Hart B. J. Sensitive gas chromatographic method for the determination of diazepam and N-desmethyldiazepam in plasma. J Chromatogr. 1979 Jul 21;163(3):304–309. doi: 10.1016/s0378-4347(00)81419-x. [DOI] [PubMed] [Google Scholar]