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. 1986 Oct;22(4):469–474. doi: 10.1111/j.1365-2125.1986.tb02919.x

Comparison of the effects of penbutolol and propranolol on glomerular filtration rate in hypertensive patients with impaired renal function.

J van der Meulen, E Reijn, G A Heidendal, P L Oe, A J Donker
PMCID: PMC1401151  PMID: 3533129

Abstract

Penbutolol and propranolol were administered orally in a dosage of 40 mg once daily and 80 mg twice daily, respectively to 12 patients with hypertension and impaired renal function. Both drugs caused a significant decrease in mean arterial pressure and heart rate. Serum creatinine concentration increased significantly by 10% during therapy with propranolol without concomitant decrease in creatinine clearance. No such effect was seen with penbutolol. GFR measured with [125I]-iothalamate showed no significant changes with both drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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