Abstract
In 14 patients receiving chronic amiodarone therapy the appearance of multilamellar inclusion bodies in peripheral blood neutrophils was related to both plasma concentrations of amiodarone and its desethyl metabolite and unwanted effects of the drug. Seven of the patients had well defined inclusion bodies. In this group mean amiodarone and desethylamiodarone concentrations were significantly higher than in the remaining seven patients and all but one had unwanted effects of the drug. Of the seven patients without inclusion bodies only one, with high plasma amiodarone and desethylamiodarone concentrations, had unwanted effects of the drug. It is concluded that the appearance of multilamellar bodies in the blood neutrophils of amiodarone-treated patients may help to distinguish those patients at risk of long-term amiodarone toxicity.
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Selected References
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- Adams P. C., Holt D. W., Storey G. C., Morley A. R., Callaghan J., Campbell R. W. Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy. Circulation. 1985 Nov;72(5):1064–1075. doi: 10.1161/01.cir.72.5.1064. [DOI] [PubMed] [Google Scholar]
- Dake M. D., Madison J. M., Montgomery C. K., Shellito J. E., Hinchcliffe W. A., Winkler M. L., Bainton D. F. Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity. Am J Med. 1985 Mar;78(3):506–512. doi: 10.1016/0002-9343(85)90346-8. [DOI] [PubMed] [Google Scholar]
- Holt D. W., Tucker G. T., Jackson P. R., McKenna W. J. Amiodarone pharmacokinetics. Br J Clin Pract Suppl. 1986 Apr;44:109–114. [PubMed] [Google Scholar]
- Holt D. W., Tucker G. T., Jackson P. R., Storey G. C. Amiodarone pharmacokinetics. Am Heart J. 1983 Oct;106(4 Pt 2):840–847. doi: 10.1016/0002-8703(83)90006-6. [DOI] [PubMed] [Google Scholar]
- Storey G. C., Holt D. W., Holt P., Curry P. V. High-performance liquid chromatographic measurement of amiodarone and its desethyl metabolite: methodology and preliminary observations. Ther Drug Monit. 1982;4(4):385–388. doi: 10.1097/00007691-198212000-00009. [DOI] [PubMed] [Google Scholar]