Abstract
Twelve volunteer poor sleepers of mean age 57 years took placebo on each of 3 consecutive nights, and temelastine 100 mg on 3 consecutive nights in a double-blind balanced order study. Sleep in the EEG laboratory was unaffected by the drug.
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Selected References
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- Adam K., Oswald I. The hypnotic effects of an antihistamine: promethazine. Br J Clin Pharmacol. 1986 Dec;22(6):715–717. doi: 10.1111/j.1365-2125.1986.tb02962.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Betts T., Markman D., Debenham S., Mortiboy D., McKevitt T. Effects of two antihistamine drugs on actual driving performance. Br Med J (Clin Res Ed) 1984 Jan 28;288(6413):281–282. doi: 10.1136/bmj.288.6413.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown E. A., Griffiths R., Harvey C. A., Owen D. A. Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system. Br J Pharmacol. 1986 Mar;87(3):569–578. doi: 10.1111/j.1476-5381.1986.tb10199.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hindmarch I., Parrott A. C. A repeated dose comparison of the side effects of five antihistamines on objective assessments of psychomotor performance, central nervous system arousal and subjective appraisals of sleep and early morning behaviour. Arzneimittelforschung. 1978;28(3):483–486. [PubMed] [Google Scholar]
- Roehrs T. A., Tietz E. I., Zorick F. J., Roth T. Daytime sleepiness and antihistamines. Sleep. 1984;7(2):137–141. doi: 10.1093/sleep/7.2.137. [DOI] [PubMed] [Google Scholar]
