Abstract
1 A simple and specific procedure is described for the determination of the new anti-depressant trazodone in human plasma utilising reverse-phase HPLC which is sensitive to 20 ng ml-1. 2 Following oral administration of single 50 mg doses of two formulations of trazodone on separate occasions to healthy fasted volunteers, the peak plasma concentration, time to peak concentration, area under the curve, elimination rate constant and half-life were determined. 3 The two formulations are closely similar and they are considered to have comparable bioavailability.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allori L., Catanese B., Cioli V., Interdonato N. A study of serum levels of trazodone produced in man following single or repeated oral administrations. Boll Chim Farm. 1978 Sep;117(9):530–533. [PubMed] [Google Scholar]
- Baiocchi L., Chiari A., Frigerio A., Ridolfi P. Analytical profile of trazodone. Arzneimittelforschung. 1973 Mar;23(3):400–406. [PubMed] [Google Scholar]
- Baiocchi L., Frigerio A., Giannangeli M., Palazzo G. Basic metabolites of trazodone in humans. Arzneimittelforschung. 1974 Oct;24(10):1699–1706. [PubMed] [Google Scholar]
- Ban T. A., Lehmann H. E. Systematic clinical studies with trazodone: methodological aspects. Curr Ther Res Clin Exp. 1973 Oct;15(10):764–768. [PubMed] [Google Scholar]
- Catanese B., Lisciani R. Investigations on the absorption and distribution of trazodone or AF 1161 in rats, dogs and humans. Boll Chim Farm. 1970 Jun;109(6):369–373. [PubMed] [Google Scholar]
- Jauch R., Kopitar Z., Prox A., Zimmer A. Pharmakokinetik und Stoffwechsel von Trazodone beim Menschen. Arzneimittelforschung. 1976;26(11):2084–2089. [PubMed] [Google Scholar]
- Munday B., Kendall M. J., Mitchard M. A single dose study of trazodone with an assessment of its effect on mood and arousal. Br J Clin Pharmacol. 1975 Feb;2(1):19–24. doi: 10.1111/j.1365-2125.1975.tb00466.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Palazzo G. Chemistry of trazodone. Curr Ther Res Clin Exp. 1973 Oct;15(10):745–748. [PubMed] [Google Scholar]
- Silverstrini B., Lisciani R. Pharmacology of trazodone. Curr Ther Res Clin Exp. 1973 Oct;15(10):749–754. [PubMed] [Google Scholar]
- Silvestrini B., Cioli V., Burberi S., Catanese B. Pharmacological properties of AF 1161, a new psychotropic drug. Int J Neuropharmacol. 1968 Nov;7(6):587–599. doi: 10.1016/0028-3908(68)90069-5. [DOI] [PubMed] [Google Scholar]
- Udabe R. U. Clinical experience with a new psychotropic drug, trazodone: a review of literature. Curr Ther Res Clin Exp. 1973 Oct;15(10):755–763. [PubMed] [Google Scholar]
- Wheatley D. Evaluation of trazodone in the treatment of anxiety. Curr Ther Res Clin Exp. 1976 Jul;20(1):74–83. [PubMed] [Google Scholar]