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. 1981 May;11(5):491–496. doi: 10.1111/j.1365-2125.1981.tb01155.x

Physiological and pharmacological variability in estimated hepatic blood flow in man.

T K Daneshmend, L Jackson, C J Roberts
PMCID: PMC1401606  PMID: 6115663

Abstract

1 Changes in hepatic blood flow have been estimated by measurement of single-dose indocyanine green kinetics in groups of healthy individuals. 2 The effects of change in posture, exercise and ingestion of milk on estimated hepatic blood flow have been assessed. 3 The erect posture and exercise significantly decreased ICG clearance. However, no consistent change was noted after ingestion of milk. 4 The effects of the adrenoceptor blocking drugs phenoxybenzamine, propranolol and labetalol on hepatic blood flow were also assessed. 5 Propranolol and labetalol caused a significant fall in ICG clearance in the supine position. Phenoxybenzamine did not show a consistent change. 6 Posture, exercise and adrenoceptor blockade appear to be important variables affecting hepatic blood flow. They should be considered when kinetics of high-clearance drugs are measured, and may provide a useful model for the assessment of the effects of alterations in hepatic blood flow on the clearance of drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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