Abstract
1 A new technique for determining venous compliance at a standardized congestion pressure has been developed based on the optical method described by Nachev, Collier & Robinson (1971). It uses a linear variable differential transformer for a direct and continuous recording of venous compliance. 2 This method has been used to establish dose-response curves for the constrictor effects of noradrenaline, adrenaline, 5-hydroxytryptamine and dihydroergotamine after direct local infusion. 3 A parallel shift to the right of the noradrenaline dose-response curves was observed after local infusion of phentolamine, showing that the method can be used also to study interactions between agonists and antagonists on human veins in vivo. The usefulness of this technique for investigating the effects of orally administered drugs has also been established. The venoconstrictor action of dihydroergotamine reached its maximum after 1.5 h and remained almost constant for the period of observation (8 h).
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aellig W. H. Use of a linear variable differential transformer to measure compliance of human hand veins in situ [proceedings]. Br J Clin Pharmacol. 1979 Oct;8(4):395P–395P. doi: 10.1111/j.1365-2125.1979.tb04742.x. [DOI] [PubMed] [Google Scholar]
- Aellig W. H. Venoconstrictor effect of dihydroergotamine in superficial hand veins. Eur J Clin Pharmacol. 1974;7(2):137–139. doi: 10.1007/BF00561328. [DOI] [PubMed] [Google Scholar]
- Aminu J. M., Vere D. W. The effects of oral propranolol on the distensibility of resting superficial veins in man. Clin Sci. 1972 Jan;42(1):3P–3P. doi: 10.1042/cs042003p. [DOI] [PubMed] [Google Scholar]
- Aminu J., Vere D. W. A longitudinal study of the mechanisms of action of debrisoquine and propranolol. Br J Clin Pharmacol. 1978 Jul;6(1):43–50. doi: 10.1111/j.1365-2125.1978.tb01680.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carroll P. R., Ebeling P. W., Glover W. E. The responses of the human temporal and rabbit ear artery to 5-hydroxytryptamine and some of its antagonists. Aust J Exp Biol Med Sci. 1974 Oct;52(5):813–823. doi: 10.1038/icb.1974.80. [DOI] [PubMed] [Google Scholar]
- Collier J. G., Nachev C., Robinson B. F. Effect of catecholamines and other vasoactive substances on superficial hand veins in man. Clin Sci. 1972 Sep;43(3):455–467. doi: 10.1042/cs0430455. [DOI] [PubMed] [Google Scholar]
- Müller-Schweinitzer E. Studies on the peripheral mode of action of dihydroergotamine in human and canine veins. Eur J Pharmacol. 1974 Jul;27(2):231–237. doi: 10.1016/0014-2999(74)90150-2. [DOI] [PubMed] [Google Scholar]
- Nachev C., Collier J., Robinson B. Simplified method for measuring compliance of superficial veins. Cardiovasc Res. 1971 Jan;5(1):147–156. doi: 10.1093/cvr/5.1.147. [DOI] [PubMed] [Google Scholar]
- Robinson B. F. Assessment of the effect of drugs on the venous system in man. Br J Clin Pharmacol. 1978 Nov;6(5):381–386. doi: 10.1111/j.1365-2125.1978.tb04600.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sicuteri F., Del Bianco P. L., Fanciullacci M., Franchi G. Il test della venocostrizione per la misura della sensibilità alla 5-idrossitriptamina e alle catecolamine nell'uomo. Boll Soc Ital Biol Sper. 1964 Oct 15;40(19):1148–1150. [PubMed] [Google Scholar]
- White C. B., Udwadia B. P. Beta-adrenoceptors in the human dorsal hand vein, and the effects of propranolol and practolol on venous sensitivity to noradrenaline. Br J Clin Pharmacol. 1975 Apr;2(2):99–105. doi: 10.1111/j.1365-2125.1975.tb01564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]