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. 1981;11(Suppl 1):5S–9S. doi: 10.1111/j.1365-2125.1981.tb01832.x

The use of benzodiazepines in clinical practice

R I Shader, D J Greenblatt
PMCID: PMC1401641  PMID: 6133535

Abstract

1 The pharmacokinetic characteristics of the six benzodiazepine anxiolytic drugs available in the United States are reviewed.

2 Concern over the abuse potential of the benzodiazepine class of drugs is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abruzzo C. W., Macasieb T., Weinfeld R., Rider J. A., Kaplan S. A. Changes in the oral absorption characteristics in man of dipotassium clorazepate at normal and elevated gastric pH. J Pharmacokinet Biopharm. 1977 Aug;5(4):377–390. doi: 10.1007/BF01061697. [DOI] [PubMed] [Google Scholar]
  2. Greenblatt D. J., Allen M. D., Harmatz J. S., Shader R. I. Diazepam disposition determinants. Clin Pharmacol Ther. 1980 Mar;27(3):301–312. doi: 10.1038/clpt.1980.40. [DOI] [PubMed] [Google Scholar]
  3. Greenblatt D. J., Allen M. D., Locniskar A., Harmatz J. S., Shader R. I. Lorazepam kinetics in the elderly. Clin Pharmacol Ther. 1979 Jul;26(1):103–113. doi: 10.1002/cpt1979261103. [DOI] [PubMed] [Google Scholar]
  4. Greenblatt D. J., Shader R. I. Dependence, tolerance, and addiction to benzodiazepines: clinical and pharmacokinetic considerations. Drug Metab Rev. 1978;8(1):13–28. doi: 10.3109/03602537808993775. [DOI] [PubMed] [Google Scholar]
  5. Greenblatt D. J., Shader R. I., Franke K., MacLaughlin D. S., Harmatz J. S., Allen M. D., Werner A., Woo E. Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans. J Pharm Sci. 1979 Jan;68(1):57–63. doi: 10.1002/jps.2600680119. [DOI] [PubMed] [Google Scholar]
  6. Greenblatt D. J., Shader R. I., MacLeod S. M., Sellers E. M., Franke K., Giles H. G. Absorption of oral and intramuscular chlordiazepoxide. Eur J Clin Pharmacol. 1978 Jun 19;13(4):267–274. doi: 10.1007/BF00716362. [DOI] [PubMed] [Google Scholar]
  7. Greenblatt D. J., Shader R. I. Prazepam and lorazepam, two new benzodiazepines. N Engl J Med. 1978 Dec 14;299(24):1342–1344. doi: 10.1056/NEJM197812142992405. [DOI] [PubMed] [Google Scholar]
  8. Greenblatt D. J., Woo E., Allen M. D., Orsulak P. J., Shader R. I. Rapid recovery from massive diazepam overdose. JAMA. 1978 Oct 20;240(17):1872–1874. [PubMed] [Google Scholar]
  9. Klotz U., Avant G. R., Hoyumpa A., Schenker S., Wilkinson G. R. The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest. 1975 Feb;55(2):347–359. doi: 10.1172/JCI107938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ochs H. R., Greenblatt D. J., Allen M. D., Harmatz J. S., Shader R. I., Bodem G. Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate. Clin Pharmacol Ther. 1979 Oct;26(4):449–456. doi: 10.1002/cpt1979264449. [DOI] [PubMed] [Google Scholar]
  11. Pevnick J. S., Jasinski D. R., Haertzen C. A. Abrupt withdrawal from therapeutically administered diazepam. Report of a case. Arch Gen Psychiatry. 1978 Aug;35(8):995–998. doi: 10.1001/archpsyc.1978.01770320089008. [DOI] [PubMed] [Google Scholar]
  12. Roberts R. K., Wilkinson G. R., Branch R. A., Schenker S. Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium). Gastroenterology. 1978 Sep;75(3):479–485. [PubMed] [Google Scholar]
  13. Sellers E. M., Greenblatt D. J., Giles H. G., Naranjo C. A., Kaplan H., MacLeod S. M. Chlordiazepoxide and oxazepam disposition in cirrhosis. Clin Pharmacol Ther. 1979 Aug;26(2):240–246. doi: 10.1002/cpt1979262240. [DOI] [PubMed] [Google Scholar]
  14. Shader R. I., Georgotas A., Greenblatt D. J., Harmatz J. S., Allen M. D. Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide. Clin Pharmacol Ther. 1978 Sep;24(3):308–315. doi: 10.1002/cpt1978243308. [DOI] [PubMed] [Google Scholar]
  15. Shader R. I., Greenblatt D. J., Harmatz J. S., Franke K., Koch-Weser J. Absorption and disposition of chlordiazepoxide in young and elderly male volunteers. J Clin Pharmacol. 1977 Nov-Dec;17(11-12):709–718. doi: 10.1002/j.1552-4604.1977.tb01546.x. [DOI] [PubMed] [Google Scholar]
  16. Shull H. J., Wilkinson G. R., Johnson R., Schenker S. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. Ann Intern Med. 1976 Apr;84(4):420–425. doi: 10.7326/0003-4819-84-4-420. [DOI] [PubMed] [Google Scholar]

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