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. 1981;11(Suppl 1):37S–42S. doi: 10.1111/j.1365-2125.1981.tb01837.x

Approaches in the evaluation of hypnotics

Studies with triazolam

R P Purpura
PMCID: PMC1401649  PMID: 6133533

Abstract

1 The evaluation of an hypnotic may be approached from the view that insomnia is a primary disease or the symptom of an underlying emotional or physical problem.

2 The two approaches have been used in the investigation of triazolam.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chatwin J. C., Johns W. L. Triazolam: an effective hypnotic in general practice. Curr Ther Res Clin Exp. 1977 Feb;21(2):207–214. [PubMed] [Google Scholar]
  2. Fabre L. F., Jr, Gross L., Pasigajen V., Metzler C. Multiclinic double-blind comparison of triazolam and flurazepam for seven nights in outpatients with insomnia. J Clin Pharmacol. 1977 Jul;17(7):402–409. doi: 10.1002/j.1552-4604.1977.tb04623.x. [DOI] [PubMed] [Google Scholar]
  3. Fabre L. F., Jr, Smith W. T. Multi-clinic cross-over comparison of triazolam (Halcion) and placebo in the treatment of co-existing insomnia and anxiety in anxious out-patients. Dis Nerv Syst. 1977 Jun;38(6):487–491. [PubMed] [Google Scholar]
  4. Jick H., Slone D., Dinan B., Muench H. Evaluation of drug efficacy by a preference technic. N Engl J Med. 1966 Dec 22;275(25):1399–1403. doi: 10.1056/NEJM196612222752502. [DOI] [PubMed] [Google Scholar]
  5. Kales A., Kales J. D., Bixler E. O., Scharf M. B., Russek E. Hypnotic efficacy of triazolam: sleep laboratory evaluation of intermediate-term effectiveness. J Clin Pharmacol. 1976 Aug-Sep;16(8-9):399–406. doi: 10.1002/j.1552-4604.1976.tb02414.x. [DOI] [PubMed] [Google Scholar]
  6. Kales A., Scharf M. B., Kales J. D. Rebound insomnia: a new clinical syndrome. Science. 1978 Sep 15;201(4360):1039–1041. doi: 10.1126/science.684426. [DOI] [PubMed] [Google Scholar]
  7. Leibowitz M., Sunshine A. Long-term hypnotic efficacy and safety of triazolam and flurazepam. J Clin Pharmacol. 1978 May-Jun;18(5-6):302–309. doi: 10.1002/j.1552-4604.1978.tb02450.x. [DOI] [PubMed] [Google Scholar]
  8. Matta B., Franco A. E., Le Zotte L. A., Rudzik A. D., Veldkamp W. Comparison of triazolam, flurazepam and placebo as hypnotic agents in pre-surgical patients. Curr Ther Res Clin Exp. 1974 Sep;16(9):958–963. [PubMed] [Google Scholar]
  9. Nicholson A. N., Stone B. M. Activity of the hypnotics, flunitrazepam and triazolam, in man. Br J Clin Pharmacol. 1980 Feb;9(2):187–194. doi: 10.1111/j.1365-2125.1980.tb05832.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Okawa K. K., Allens G. S. A clinical comparison of triazolam with placebo and with secobarbital in insomniac patients. J Int Med Res. 1978;6(4):343–347. doi: 10.1177/030006057800600413. [DOI] [PubMed] [Google Scholar]
  11. Reeves R. L. Comparison of triazolam, flurazepam, and placebo as hypnotics in geriatric patients with insomnia. J Clin Pharmacol. 1977 May-Jun;17(5-6):319–323. doi: 10.1002/j.1552-4604.1977.tb04611.x. [DOI] [PubMed] [Google Scholar]
  12. Rickels K., Gingrich R. L., Jr, Morris R. J., Rosenfeld H., Perloff M. M., Clark E. L., Schilling A. Triazolam in insomniac family practice patients. Clin Pharmacol Ther. 1975 Sep;18(3):315–324. doi: 10.1002/cpt1975183315. [DOI] [PubMed] [Google Scholar]
  13. Roth T., Kramer M., Lutz T. Intermediate use of triazolam: a sleep laboratory study. J Int Med Res. 1976;4(1):59–63. doi: 10.1177/030006057600400109. [DOI] [PubMed] [Google Scholar]
  14. Roth T., Kramer M., Schwartz J. L. Triazolam: a sleep laboratory study of a new benzodiazepine hypnotic. Curr Ther Res Clin Exp. 1974 Feb;16(2):117–123. [PubMed] [Google Scholar]
  15. Schwartz J. L., Kramer M., Roth T. Triazolam: a new benzodiazepine hypnotic and its effect on mood. Curr Ther Res Clin Exp. 1974 Sep;16(9):964–970. [PubMed] [Google Scholar]
  16. Sunshine A. Comparison of the hypnotic activity of triazolam, flurazepam hydrochloride, and placebo. Clin Pharmacol Ther. 1975 May;17(5):573–577. doi: 10.1002/cpt1975175573. [DOI] [PubMed] [Google Scholar]
  17. Vogel G. W., Barker K., Gibbons P., Thurmond A. A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs. Psychopharmacology (Berl) 1976 May 5;47(1):81–86. doi: 10.1007/BF00428706. [DOI] [PubMed] [Google Scholar]
  18. Vogel G., Thurmond A., Gibbons P., Edwards K., Sloan K. B., Sexton K. The effect of triazolam on the sleep of insomniacs. Psychopharmacologia. 1975;41(1):65–69. doi: 10.1007/BF00421308. [DOI] [PubMed] [Google Scholar]

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