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. 1981 Apr;11(4):319–332. doi: 10.1111/j.1365-2125.1981.tb01128.x

The clinical assessment of analgesic drugs.

D W Littlejohns, D W Vere
PMCID: PMC1401660  PMID: 7259924

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Selected References

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  1. ARMSTRONG D., DRY R. M. L., KEELE C. A., MARKHAM J. W. Observations on chemical excitants of cutaneous pain in man. J Physiol. 1953 May 28;120(3):326–351. doi: 10.1113/jphysiol.1953.sp004898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aitken R. C. Measurement of feelings using visual analogue scales. Proc R Soc Med. 1969 Oct;62(10):989–993. [PMC free article] [PubMed] [Google Scholar]
  3. Axelsen R. A. Nephrotoxicity of mild analgesics in the Gunn strain of rat. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):309S–312S. doi: 10.1111/j.1365-2125.1980.tb01814.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BEECHER H. K. The measurement of pain; prototype for the quantitative study of subjective responses. Pharmacol Rev. 1957 Mar;9(1):59–209. [PubMed] [Google Scholar]
  5. Bailey C. A., Davidson P. O. The language of pain: intensity. Pain. 1976 Sep;2(3):319–324. doi: 10.1016/0304-3959(76)90010-5. [DOI] [PubMed] [Google Scholar]
  6. Beaver W. T., McMillan D. Methodological considerations in the evaluation of analgesic combinations: acetaminophen (paracetamol) and hydrocodone in postpartum pain. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):215S–223S. [PMC free article] [PubMed] [Google Scholar]
  7. Berkowitz B. A. The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone. Clin Pharmacokinet. 1976;1(3):219–230. doi: 10.2165/00003088-197601030-00004. [DOI] [PubMed] [Google Scholar]
  8. Bloomfield S. S., Barden T. P., Mitchell J. Asprin and codeine in two postpartum pain models. Clin Pharmacol Ther. 1976 Oct;20(4):499–503. doi: 10.1002/cpt1976204499. [DOI] [PubMed] [Google Scholar]
  9. Buchsbaum M. S., Davis G. C., Bunney W. E., Jr Naloxone alters pain perception and somatosensory evoked potentials in normal subjects. Nature. 1977 Dec 15;270(5638):620–622. doi: 10.1038/270620a0. [DOI] [PubMed] [Google Scholar]
  10. Chapman C. R., Murphy T. M., Butler S. H. Analgesic strength of 33 percent nitrous oxide: a signal detection theory evaluation. Science. 1973 Mar 23;179(4079):1246–1248. doi: 10.1126/science.179.4079.1246. [DOI] [PubMed] [Google Scholar]
  11. Chapman C. R. Sensory decision theory methods in pain research: a reply to Rollman. Pain. 1977 Aug;3(4):295–305. doi: 10.1016/0304-3959(77)90062-8. [DOI] [PubMed] [Google Scholar]
  12. Clark W. C. Pain sensitivity and the report of pain: an introduction to sensory decision theory. Anesthesiology. 1974 Mar;40(3):272–287. doi: 10.1097/00000542-197403000-00014. [DOI] [PubMed] [Google Scholar]
  13. Cooper S. A., Beaver W. T. A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther. 1976 Aug;20(2):241–250. doi: 10.1002/cpt1976202241. [DOI] [PubMed] [Google Scholar]
  14. Craig K. D., Neidermayer H. Autonomic correlates of pain thresholds influenced by social modeling. J Pers Soc Psychol. 1974 Feb;29(2):246–252. doi: 10.1037/h0035923. [DOI] [PubMed] [Google Scholar]
  15. Crockett D. J., Prkachin K. M., Craig K. D. Factors of the langugage of pain in patient and volunteer groups. Pain. 1977 Dec;4(2):175–182. doi: 10.1016/0304-3959(77)90131-2. [DOI] [PubMed] [Google Scholar]
  16. Deodhar S. D., Dick W. C., Hodgkinson R., Buchanan W. W. Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis. Q J Med. 1973 Apr;42(166):387–401. [PubMed] [Google Scholar]
  17. Downie W. W., Leatham P. A., Rhind V. M., Pickup M. E., Wright V. The visual analogue scale in the assessment of grip strength. Ann Rheum Dis. 1978 Aug;37(4):382–384. doi: 10.1136/ard.37.4.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Downie W. W., Leatham P. A., Rhind V. M., Wright V., Branco J. A., Anderson J. A. Studies with pain rating scales. Ann Rheum Dis. 1978 Aug;37(4):378–381. doi: 10.1136/ard.37.4.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Duggan J. M. Gastrointestinal toxicity of minor analgesics. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):407S–410S. doi: 10.1111/j.1365-2125.1980.tb01831.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Dundee J. W. Clinical evaluation of mild analgesics. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):329S–334S. doi: 10.1111/j.1365-2125.1980.tb01817.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Evans R. J. Acid-base changes in patients with intractable pain and malignancy. Can J Surg. 1972 Jan;15(1):37–42. [PubMed] [Google Scholar]
  22. Finney D. J. Statisical logic in the monitoring of reactions to therapeutic drugs. Methods Inf Med. 1971 Oct;10(4):237–245. [PubMed] [Google Scholar]
  23. Fowle A. S., Hughes D. T., Knight G. J. The evaluation of histamine antagonists in man. Eur J Clin Pharmacol. 1971 Sep;3(4):215–220. doi: 10.1007/BF00565009. [DOI] [PubMed] [Google Scholar]
  24. Glynn C. J., Lloyd J. W. The diurnal variation in perception of pain. Proc R Soc Med. 1976 May;69(5):369–372. [PMC free article] [PubMed] [Google Scholar]
  25. Gracely R. H., McGrath F., Dubner R. Ratio scales of sensory and affective verbal pain descriptors. Pain. 1978 Jun;5(1):5–18. doi: 10.1016/0304-3959(78)90020-9. [DOI] [PubMed] [Google Scholar]
  26. Gracely R. H., McGrath P., Dubner R. Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: manipulation of affect by diazepam. Pain. 1978 Jun;5(1):19–29. doi: 10.1016/0304-3959(78)90021-0. [DOI] [PubMed] [Google Scholar]
  27. Gómez-Jiménez J., Franco-Patino R., Chargoy-Vera J., Olivares-Sosa R. Clinical efficacy of mild analgesics in pain following gynaecological or dental surgery: report on multicentre studies. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):355S–358S. doi: 10.1111/j.1365-2125.1980.tb01823.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. HEWER A. J. H., KEELE C. A. A clinical method of assessing analgesics. Lancet. 1949 Mar 12;1(6550):431–435. doi: 10.1016/s0140-6736(49)90753-9. [DOI] [PubMed] [Google Scholar]
  29. HOUDE R. W., WALLENSTEIN S. L., ROGERS A. Clinical pharmacology of analgesics. 1. A method of assaying analgesic effect. Clin Pharmacol Ther. 1960 Mar-Apr;1:163–174. doi: 10.1002/cpt196012163. [DOI] [PubMed] [Google Scholar]
  30. Hardy J. D., Wolff H. G., Goodell H. STUDIES ON PAIN. A NEW METHOD FOR MEASURING PAIN THRESHOLD: OBSERVATIONS ON SPATIAL SUMMATION OF PAIN. J Clin Invest. 1940 Jul;19(4):649–657. doi: 10.1172/JCI101168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Hardy J. D., Wolff H. G., Goodell H. STUDIES ON PAIN: DISCRIMINATION OF DIFFERENCES IN INTENSITY OF A PAIN STIMULUS AS A BASIS OF A SCALE OF PAIN INTENSITY. J Clin Invest. 1947 Nov;26(6):1152–1158. doi: 10.1172/JCI101907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Hills M., Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol. 1979 Jul;8(1):7–20. doi: 10.1111/j.1365-2125.1979.tb05903.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Hindmarch I. Psychomotor function and psychoactive drugs. Br J Clin Pharmacol. 1980 Sep;10(3):189–209. doi: 10.1111/j.1365-2125.1980.tb01745.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Hunter M., Philips C., Rachman S. Memory for pain. Pain. 1979 Feb;6(1):35–46. doi: 10.1016/0304-3959(79)90138-6. [DOI] [PubMed] [Google Scholar]
  35. Huskisson E. C. Catecholamine excretion and pain. Br J Clin Pharmacol. 1974 Feb;1(1):80–82. doi: 10.1111/j.1365-2125.1974.tb00211.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Huskisson E. C., Hart F. D. Pain threshold and arthritis. Br Med J. 1972 Oct 28;4(5834):193–195. doi: 10.1136/bmj.4.5834.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Huskisson E. C. Measurement of pain. Lancet. 1974 Nov 9;2(7889):1127–1131. doi: 10.1016/s0140-6736(74)90884-8. [DOI] [PubMed] [Google Scholar]
  38. Jasinski D. R. Human pharmacology of narcotic antagonists. Br J Clin Pharmacol. 1979;7 (Suppl 3):287S–290S. doi: 10.1111/j.1365-2125.1979.tb04702.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Jennett S. Assessment of respiratory effects of analgesic drugs. Br J Anaesth. 1968 Oct;40(10):746–756. doi: 10.1093/bja/40.10.746. [DOI] [PubMed] [Google Scholar]
  40. Jick H., Slone D., Shapiro S., Lewis G. P., Siskind V. A new method for assessing the clinical effects of oral analgesic drugs. Clin Pharmacol Ther. 1971 May-Jun;12(3):456–463. doi: 10.1002/cpt1971123456. [DOI] [PubMed] [Google Scholar]
  41. Johnson P. C. A comparison of the effects of zomepirac and aspirin on fecal blood loss. J Clin Pharmacol. 1980 May-Jun;20(5-6):401–405. [PubMed] [Google Scholar]
  42. Joyce C. R., Zutshi D. W., Hrubes V., Mason R. M. Comparison of fixed interval and visual analogue scales for rating chronic pain. Eur J Clin Pharmacol. 1975 Aug 14;8(6):415–420. doi: 10.1007/BF00562315. [DOI] [PubMed] [Google Scholar]
  43. KAST E. C. The measurement of pain: a new approach to an old problem. J New Drugs. 1962 Nov-Dec;2:344–351. doi: 10.1177/009127006200200604. [DOI] [PubMed] [Google Scholar]
  44. KEELE K. D. Pain-sensitivity tests; the pressure algometer. Lancet. 1954 Mar 27;266(6813):636–639. doi: 10.1016/s0140-6736(54)92347-8. [DOI] [PubMed] [Google Scholar]
  45. KEELE K. D. The pain chart. Lancet. 1948 Jul 3;2(6514):6–8. doi: 10.1016/s0140-6736(48)91787-5. [DOI] [PubMed] [Google Scholar]
  46. Keele K. D. Pain complaint threshold in relation to pain of cardiac infarction. Br Med J. 1968 Mar 16;1(5593):670–673. doi: 10.1136/bmj.1.5593.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Knitza R., Clasen R., Fischer F. Pain-induced alterations in the individual non-esterified fatty acids in serum. Pain. 1979 Feb;6(1):91–97. doi: 10.1016/0304-3959(79)90143-X. [DOI] [PubMed] [Google Scholar]
  48. LASAGNA L. The clinical measurement of pain. Ann N Y Acad Sci. 1960 Mar 30;86:28–37. doi: 10.1111/j.1749-6632.1960.tb42788.x. [DOI] [PubMed] [Google Scholar]
  49. Lasagna L. Analgesic methodology: a brief history and commentary. J Clin Pharmacol. 1980 May-Jun;20(5-6):373–376. [PubMed] [Google Scholar]
  50. Lascelles P. T., Evans P. R., Merskey H., Sabur M. A. Plasma control in psychiatric and neurological patients with pain. Brain. 1974 Sep;97(3):533–538. doi: 10.1093/brain/97.1.533. [DOI] [PubMed] [Google Scholar]
  51. Laska E., Sunshine A. Anticipation of analgesia. A placebo effect. Headache. 1973 Apr;13(1):1–11. doi: 10.1111/j.1526-4610.1973.hed1301001.x. [DOI] [PubMed] [Google Scholar]
  52. Levine J. D., Gordon N. C., Bornstein J. C., Fields H. L. Role of pain in placebo analgesia. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3528–3531. doi: 10.1073/pnas.76.7.3528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Levy G. Clinical pharmacokinetics of salicylates: a re-assessment. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):285S–290S. doi: 10.1111/j.1365-2125.1980.tb01811.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Lynn B., Perl E. R. A comparison of four tests for assessing the pain sensitivity of different subjects and test areas. Pain. 1977 Aug;3(4):353–365. doi: 10.1016/0304-3959(77)90065-3. [DOI] [PubMed] [Google Scholar]
  55. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  56. MONGAR J. L. A study of two methods for testing local anaesthetics in man. Br J Pharmacol Chemother. 1955 Jun;10(2):240–246. doi: 10.1111/j.1476-5381.1955.tb00089.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain. 1975 Sep;1(3):277–299. doi: 10.1016/0304-3959(75)90044-5. [DOI] [PubMed] [Google Scholar]
  58. Melzack R., Torgerson W. S. On the language of pain. Anesthesiology. 1971 Jan;34(1):50–59. doi: 10.1097/00000542-197101000-00017. [DOI] [PubMed] [Google Scholar]
  59. Mielke C. H., Jr, Kahn S. B., Muschek L. D., Tighe J. J., Ng K. T., Minn F. L. Effects of zomepirac on hemostasis in healthy adults and on platelet function in vitro. J Clin Pharmacol. 1980 May-Jun;20(5-6):409–417. [PubMed] [Google Scholar]
  60. Mumford J. M., Bowsher D. Pain and protopathic sensibility. A reveiw with particular reference to the teeth. Pain. 1976 Sep;2(3):223–243. doi: 10.1016/0304-3959(76)90002-6. [DOI] [PubMed] [Google Scholar]
  61. Nanra R. S. Clinical and pathological aspects of analgesic nephropathy. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):359S–368S. doi: 10.1111/j.1365-2125.1980.tb01824.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Nathan P. W. Pain. Br Med Bull. 1977 May;33(2):149–155. doi: 10.1093/oxfordjournals.bmb.a071415. [DOI] [PubMed] [Google Scholar]
  63. Nayman J. Measurement and control of postoperative pain. Ann R Coll Surg Engl. 1979 Nov;61(6):419–426. [PMC free article] [PubMed] [Google Scholar]
  64. Ohnhaus E. E., Adler R. Methodological problems in the measurement of pain: a comparison between the verbal rating scale and the visual analogue scale. Pain. 1975 Dec;1(4):379–384. doi: 10.1016/0304-3959(75)90075-5. [DOI] [PubMed] [Google Scholar]
  65. PARKHOUSE J., HOLMES C. M. Assessing post-operative pain relief. Proc R Soc Med. 1963 Jul;56:579–585. [PMC free article] [PubMed] [Google Scholar]
  66. PATON W. D. Histamine release by compounds of simple chemical structure. Pharmacol Rev. 1957 Jun;9(2):269–328. [PubMed] [Google Scholar]
  67. POSER E. G. A simple and reliable apparatus for the measurement of pain. Am J Psychol. 1962 Jun;75:304–305. [PubMed] [Google Scholar]
  68. Pike M. C., Morrow R. H. Statistical analysis of patient-control studies in epidemiology. Factor under investigation an all-or-none variable. Br J Prev Soc Med. 1970 Feb;24(1):42–44. doi: 10.1136/jech.24.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Prescott L. F. Hepatotoxicity of mild analgesics. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):373S–379S. doi: 10.1111/j.1365-2125.1980.tb01825.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Prescott L. F. Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):291S–298S. doi: 10.1111/j.1365-2125.1980.tb01812.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Revill S. I., Robinson J. O., Rosen M., Hogg M. I. The reliability of a linear analogue for evaluating pain. Anaesthesia. 1976 Nov;31(9):1191–1198. doi: 10.1111/j.1365-2044.1976.tb11971.x. [DOI] [PubMed] [Google Scholar]
  72. Rollman G. B. Signal detection theory measurement of pain: a review and critique. Pain. 1977 Jun;3(3):187–211. doi: 10.1016/0304-3959(77)90002-1. [DOI] [PubMed] [Google Scholar]
  73. Rollman G. B. Signal detection theory pain measures: empirical validation studies and adaptation-level effects. Pain. 1979 Feb;6(1):9–21. doi: 10.1016/0304-3959(79)90136-2. [DOI] [PubMed] [Google Scholar]
  74. Sauders K. B. Methods in the assessment of the control of breathing. Br J Clin Pharmacol. 1980 Jan;9(1):3–9. doi: 10.1111/j.1365-2125.1980.tb04789.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Scott J., Huskisson E. C. Graphic representation of pain. Pain. 1976 Jun;2(2):175–184. [PubMed] [Google Scholar]
  76. Sitaram N., Buchsbaum M. S., Gillin J. C. Physostigmine analgesia and somatosensory evoked responses in man. Eur J Pharmacol. 1977 Apr 7;42(3):285–290. doi: 10.1016/0014-2999(77)90295-3. [DOI] [PubMed] [Google Scholar]
  77. Smith G. M., Egbert L. D., Markowitz R. A., Mosteller F., Beecher H. K. An experimental pain method sensitive to morphine in man: the submaximum effort tourniquet technique. J Pharmacol Exp Ther. 1966 Nov;154(2):324–332. [PubMed] [Google Scholar]
  78. Smith G. M., Lowenstein E., Hubbard J. H., Beecher H. K. Experimental pain produced by the submaximum effort tourniquet technique: further evidence of validity. J Pharmacol Exp Ther. 1968 Oct;163(2):468–474. [PubMed] [Google Scholar]
  79. Sunshine A. Clinical evaluation of mild analgesics in post partum pain. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):335S–337S. doi: 10.1111/j.1365-2125.1980.tb01818.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Swets J. A. The Relative Operating Characteristic in Psychology: A technique for isolating effects of response bias finds wide use in the study of perception and cognition. Science. 1973 Dec 7;182(4116):990–1000. doi: 10.1126/science.182.4116.990. [DOI] [PubMed] [Google Scholar]
  81. Szczeklik A. Analgesics, allergy and asthma. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):401S–405S. doi: 10.1111/j.1365-2125.1980.tb01830.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Vallbo A. B., Hagbarth K. E. Activity from skin mechanoreceptors recorded percutaneously in awake human subjects. Exp Neurol. 1968 Jul;21(3):270–289. doi: 10.1016/0014-4886(68)90041-1. [DOI] [PubMed] [Google Scholar]
  83. Van Buren J., Kleinknecht R. A. An evaluation of the McGill pain questionnaire for use in dental pain assessment. Pain. 1979 Feb;6(1):23–33. doi: 10.1016/0304-3959(79)90137-4. [DOI] [PubMed] [Google Scholar]
  84. Wallenstein S. L., Heidrich G., 3rd, Kaiko R., Houde R. W. Clinical evaluation of mild analgesics: the measurement of clinical pain. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):319S–327S. doi: 10.1111/j.1365-2125.1980.tb01816.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Wolff B. B., Kantor T. G., Jarvik M. E., Laska E. Response of experimental pain to analgesic drugs. 3. Codeine, aspirin, secobarbital, and placebo. Clin Pharmacol Ther. 1969 Mar-Apr;10(2):217–228. doi: 10.1002/cpt1969102217. [DOI] [PubMed] [Google Scholar]
  86. Woodforde J. M., Merskey H. Some relationships between subjective measures of pain. J Psychosom Res. 1972 Jun;16(3):173–178. doi: 10.1016/0022-3999(72)90041-4. [DOI] [PubMed] [Google Scholar]
  87. Yaksh T. L., Rudy T. A. Narcotic analgestics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques. Pain. 1978 Apr;4(4):299–359. doi: 10.1016/0304-3959(77)90145-2. [DOI] [PubMed] [Google Scholar]
  88. Yang J. C., Clark W. C., Ngai S. H., Berkowitz B. A., Spector S. Analgesic action and pharmacokinetics of morphine and diazepam in man: an evaluation by sensory decision theory. Anesthesiology. 1979 Dec;51(6):495–502. doi: 10.1097/00000542-197912000-00003. [DOI] [PubMed] [Google Scholar]
  89. von Graffenried B., Adler R., Abt K., Nüesch E., Spiegel R. The influence of anxiety and pain sensitivity on experimental pain in man. Pain. 1978 Feb;4(3):253–263. doi: 10.1016/0304-3959(77)90137-3. [DOI] [PubMed] [Google Scholar]
  90. von Graffenried B., Nüesch E. Non-migrainous headache for the evaluation of oral analgesics. Br J Clin Pharmacol. 1980 Oct;10 (Suppl 2):225S–231S. doi: 10.1111/j.1365-2125.1980.tb01804.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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