Abstract
1 In a multicentre study hypertensive patients whose blood pressure was inadequately controlled by thiazide diuretic alone were additionally treated with daily oral doses of 25-225 mg indoramin for periods up to 27 months.
2 Twenty-two of the 122 patients who entered the study were withdrawn because of reasons related to side-effects. Sixty-five patients completed 6 months' treatment, 54 patients received indoramin for 12 months and 11 patients completed 24 months' treatment with indoramin.
3 Twenty-eight patients were withdrawn after the diuretic phase because of adequate control of blood pressure with bendrofluazide (5 mg per day) and Slow K (2 tablets per day). Blood pressure was reduced in all but five patients. Average pre-treatment blood pressure of 182.5 (s.d. = 22.4)/110 (s.d. = 7.5, n = 122) mm Hg was reduced to 144.8 (s.d. = 18.7)/88.2 (s.d. = 7.8, n = 65) after 6 months' treatment. Blood pressure control was maintained throughout the trial.
4 There was no significant change in heart rate.
5 Body weight changes in excess of 3 kg occurred in 55 of the 122 patients. Twenty patients changed weight during the diuretic phase of whom 17 lost weight. Twenty-one patients gained weight and 17 lost weight during the treatment with indoramin plus diuretic. There was no correlation with weight change and dose of indoramin.
6 Side-effects were reported by 71 patients, the most common being sedation, dizziness, depression, constipation, headache and palpitations. These disappeared spontaneously in most patients and only 22 patients withdrew from the study because of side-effects.
7 There were no significant changes in haematological or biochemical parameters.
8 The study is continuing.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dixon G. T., Johnson E. S. Efficacy of antihypertensive drugs. Lancet. 1976 Mar 6;1(7958):515–518. doi: 10.1016/s0140-6736(76)90299-3. [DOI] [PubMed] [Google Scholar]
- Stokes G. S., Frost G. W., Graham R. M., MacCarthy E. P. Indoramin and prazosin as adjuncts to beta adrenoceptor blockade in hypertension. Clin Pharmacol Ther. 1979 Jun;25(6):783–789. doi: 10.1002/cpt1979256783. [DOI] [PubMed] [Google Scholar]